background: the phosphatidylinositol 3-kinase/akt signaling pathway is recognized as a key driver of cancer cell survival and proliferation, and is often contingent upon an impairment of expression/function of the pten tumor suppressor, a negative regulator of this pathway. in addition, the cytoskeletal signaling protein tensin 2 has also been implicated as a negative regulator of this pathway....

abstract background and aim: survivin is a new member of inhibitor of apoptosis protein family (iap) that plays an important role in the regulation of cell cycle and inhibition of apoptosis. distinct expression of this gene in tumoral cells versus normal cells introduces it as the fourth major transcriptome in cancers. thyroid carcinoma is the most common endocrine malignancy. considering the h...

a retrospective study was undertaken to examine the thyroid cancer cases referred for external radiotherapy to our department during the period of 1991-99. within this period, a total of 33 patients had been treated by irradiation for thyroid cancer or its metastases and these cases were evaluated for age, sex, pathology and type of surgery. the reason of patients’ referral for external radioth...

the treatment of thyroid cancer using an unsealed source of radioactive materials is usually associated with a large amount of 131i. a major problem for hospital admission of these patients is the waste disposal which requires protection of the public. 152 patients with thyroid cancer admitted to the nuclear medicine department of said ai- shohada hospital for ui i treatment were studied. 1311 ...

Background: The relationship between thyroid autoimmunity and breast cancer is a challenging subject. We aimed to investigate this association in women with breast cancer. Methods: In this descriptive study, 41 women with newly diagnosed breast cancer before receiving any pharmacologic treatment and 38 healthy age-matched women were enrolled. Anti TPO Ab (anti-thyroid peroxidase antibodies), FT...

personalized medicine is a set of diagnostic, prognostic and therapeutic approaches in which medical interventions are carried out based on individual patient characteristics. as life expectancy increases in developed and developing countries, the incidence of diseases such as cancer goes up among people in the community. cancer is a disease that the response to treatment varies from one person...

background: radioiodine therapy has proven to be an effective method in the treatment of patients with differentiated thyroid carcinoma after thyroidectomy. the scope of this study is to describe a method to obtain the dose of organs using medical internal radiation dosimetry (mird) method. at the end, the results of mird calculations were compared with thermoluminescent dosimeter (tld-100). ma...