Recently we have developed an assay method for peroxidase-catalyzed coupling of iodotyronine residues of thyroglobulin, which is applicable to human diseased thyroid tissues. In the present study, the assay method as well as usual peroxidase assay methods were applied to thyroids of three patients (No. 1: familial goiter with impaired thyroglobulin synthesis, No. 2: mild chronic thyroiditis, No...

background: evidences suggest an association between the prevalence of thyroid peroxidase (anti-tpo) and anti thyroglobulin (anti-tg) with recurrent abortions and infertility. iodine deficiency was once endemic in iran and little data is available about the prevalence of these antibodies in different groups of fertile or infertile individuals. objective: this case control study was designed to ...

Auto immune thyroid diseases (ATDS) are represented, essentially, by Hashimoto’s thyroiditis (HT), grave’s disease and atrophic thyroiditis [1]. Atypical marker of HT is the presence of autoantibodies against thyroglobulin and thyroid peroxidase (TPO Abs) [2]. Both genetic and environmental factors are involved in the pathogenesis of ATDS [3]. Some bacteria and viruses are suspected of being ab...

A wide array of tissues derived from all the three germinal layers is seen in ovarian teratomas. Among these, thyroid tissue is present in 10% cases of all mature cystic teratomas. We report this case of Hashimoto's thyroiditis in a clinically euthyroid patient who tested positive for antithyroid peroxidase antibodies in spite of normal thyroid hormone profile. While the histological features o...

background: premature ovarian failure (pof) is a disorder of multi causal etiology. autoimmunity has been proposed as a mechanism for some cases of ovarian follicle dysfunction which is evident in pof. the aim of this study was to identify the level of auto-antibodies in pof and familial pof patients. materials and methods: in this study, auto-antibodies including anti-ovarian antibody (aoa), a...

A linear random copolymer of tyrosine and lysine and two synthetic oligopeptides containing two tyrosine residues in addition to lysine residues give thyroid hormone (thyroxine and triodothyronine) residues in good yield upon enzymatic iodination with thyroid peroxidase. These synthetic peptides may serve as simple models for thyroglobulin, the protein in which biosynthesis of the thyroid hormo...

Background Approximately 2-4% of all women have recurrent spontaneous abortion (RSA); however, the cause is determined in only 50% of cases. Recent studies have shown an association between thyroid autoantibodies as a sign of thyroid autoimmunity and abortion. The aim of the present study was to determine whether circulating anti-thyroid peroxidase (anti-TPO) was associated with RSA. MaterialsA...

BACKGROUND AND OBJECTIVES Thyroid dysfunction is common in the elderly. We sought to explore thyroid hormone patterns in a series of elderly patients undergoing elective coronary procedures and their relation to the extent of coronary artery disease. MATERIALS AND METHODS We enrolled 81 consecutive elderly patients admitted to undergo elective diagnostic or interventional coronary procedures....

Young shoots or sprouts of common bamboos are used as food in third world countries. Evidences suggest the presence of cyanogenic glucoside like anti-thyroidal substance in bamboo shoots (BS) but effect of prolonged BS consumption on thyroid status under conditions of varying iodine nutriture remains unexplored. The study was undertaken to evaluate goitrogenic content, in vitro anti thyroid per...