We report an 11-year-old girl with euthyroid Graves' disease. She was referred to our clinic because of left exophthalmos without other symptoms suggestive of hyperthyroidism. Her serum concentration of free thyroxine (FT4) and free triiodothyronine (FT3) were normal, but thyroid-stimulating hormone (TSH) was below normal and impaired TSH response to TSH releasing hormone (TRH) was found. Altho...

Targeted therapy with tyrosine kinase inhibitors, including vascular endothelial growth factor receptors, has been demonstrated to induce hypothyroidism and thyroid dysfunction. Cancer patients with thyroid dysfunction may be underdiagnosed and undertreated. Thyroid function in colorectal cancer patients receiving fluoropyrimidine-based chemotherapy with or without bevacizumab was evaluated at ...

A thyroid disease is a medical condition impairing the function of the thyroid. The thyroid hormones act on nearly every cell in the body. Imbalance in production of thyroid hormones arises from dysfunction of the thyroid gland itself, the pituitary gland, which produces thyroid-stimulating hormone (TSH), or the hypothalamus, which regulates the pituitary gland via thyrotropin-releasing hormone...

Osteoporosis-related fractures are one of the complications of Graves' disease. This study hypothesized that the different actions of thyroid-stimulating hormone receptor (TSHR) antibodies, both stimulating and blocking activities in Graves' disease patients might oppositely impact bone turnover. Newly diagnosed premenopausal Graves' disease patients were enrolled (n = 93) and divided into two ...

Resistance to thyroid hormone (RTH) is a rare inherited syndrome characterized by diminished response of the target tissue to thyroid hormone caused, in the majority of cases, by mutation of the thyroid hormone receptor beta (THRβ) gene. Despite elevated serum levels of free thyroid hormones and thyroid stimulating hormone (TSH), the paucity of symptoms and signs of thyroid dysfunction suggest ...

OBJECTIVE An elevated thyroid stimulating hormone (TSH) level is a frequent finding in obese children, but its association with peripheral hormone metabolism is not fully understood. We hypothesized that in obesity, the changes in thyroid hormone metabolism in peripheral tissues might lead to dysregulation in the thyroid axis. The purpose of this study was to investigate the association of TSH ...

Objective: Knowing the ideal levels of triiodothyronine (T3), thyroxine (T4), FT3, FT4, and thyrotropin-stimulating hormone (TSH) for each pregnancy trimester are goal. Methods: The Department Obstetrics Gynecology at Pacific Institute Medical Sciences in Udaipur treated 150 patients (obstetric cases) current longitudinal research. following parameters were examined a fasting blood sample: T3, ...

background: much research has widely been conducted into thyroid hormones levels following radiotherapy for breast cancer. consequently, in this study, we evaluated to relate the rate of thyroid hormones levels with the dose distribution among breast cancer patients. material and methods: thirty patients were treated with 4-field breast cancer radiotherapy. the dose volume histograms, the volum...

Hypothalamic thyrotropin-releasing hormone (TRH) stimulates thyroid-stimulating hormone (TSH) secretion from the anterior pituitary. TSH then initiates thyroid hormone (TH) synthesis and release from the thyroid gland. Although opposing TRH and TH inputs regulate the hypothalamic-pituitary-thyroid axis, TH negative feedback is thought to be the primary regulator. This hypothesis, however, has y...

CASE DESCRIPTION A 56-year-old man had a thyroid-stimulating hormone (TSH) value of 22.5 IU/mL (reference interval 0.4 – 4.6 IU/mL). The increased TSH prompted review of his previous thyroid testing results (Table 1). The patient’s history revealed a diagnosis of papillary thyroid carcinoma 8 months prior, which was treated with total thyroidectomy and I radioablation followed by L-thyroxine (S...