Endocrine function has been investigated in four anencephalic neonates to determine the influence of absence of cortical and hypothalamic tissue and of hypoplasia of the pituitary. Intravenous glucose administration resulted in higher peak values for blood sugar and more rapid glucose disposal rates than reported in normals. Intravenous insulin tolerance tests on two of the infants failed to ev...

Graves' disease is caused by stimulating autoantibodies against the thyrotropin receptor inducing uncontrolled overproduction of thyroid hormones. A Bridge Assay is presented for direct detection of these thyroid-stimulating immunoglobulins using thyrotropin receptor chimeras. A capture receptor, formed by replacing aa residues 261-370 of the human thyrotropin receptor with residues 261-329 fro...

Abstract. The theoretical study of the effect of Thyrotropin Releasing Hormone in Alzheimer’s disease patients was investigated. A mathematical model using fuzzy delta shock was developed and used this model to calculate the expected time and variance of systolic blood pressure in the given time interval. The result showed that after Thyrotropin Releasing Hormone treatment, the systolic blood p...

We used an enzyme immunoassay to determine the normal reference intervals for thyroxin, triiodothyronine, and thyrotropin in groups of children, ranging from newborns to 15-year-olds. Results compared well with those by radioimmunoassay. There were no substantial differences between plasma and serum samples for thyroxin and triiodothyronine, but thyrotropin concentrations differed significantly...

The cDNA coding for dog thyrotropin (TSH) receptor was cloned from a dog thyroid library. The cloning procedure was based on the method described previously (Libert et al., 1989). The clone presented here was unambiguously identified as the thyrotropin receptor by expression in oocytes and culture cells (Parnentier et al., 1989).

Histidyl-proline diketopiperazine is produced in brain as a product of the metabolism of thyrotropin-releasing hormone. A number of the previously observed central nervous system and pituitary activities resulting from an exposure to thyrotropin-releasing hormone appear to involve the conversion of the releasing factor to the cyclic dipeptide. In the present study, the development of a rabbit a...

Pituitary tumours are a significant diagnostic problem in clinical practice. Considering all the rarity of thyrotropic hormone secreting adenoma it is and therapeutic challenge part due to lack preoperative standards. TSH-oma, besides hyperthyroidism symptoms, might be cause other endocrine disorders, most often dysfunction tropic axes may neurological symptoms associated with sella expansion. ...

BACKGROUND The thyroid cancer incidence is rising. Despite current guidelines, controversy exists regarding the degree and duration of thyrotropin suppression therapy. Also, its potential skeletal effects remain a concern to physicians caring for thyroid cancer patients. We conducted a review of published data to evaluate existing studies focusing on the skeletal effects of thyrotropin suppress...