The mechanism for the formation of thyroxine and diiodotyrosine in the thyroid gland is at present unknown. Some years ago Harington and Barger proposed that thyroxine is formed in the gland by the coupling of 2 molecules of diiodotyrosine (1). Since that time it has been demonstrated by several workers that such a reaction can occur. Von Mutzenbecher isolated thyroxine after incubating a basic...

This work was previously published in abstract form in Clin. Res. 17: 288, 1969. Dr. Larsen's present address is the Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pa. 15213. Received for publication 10 November 1969 and in revised form 4 February 1970. concentration. If free thyroxine is the only portion of the hormone available for cellular utilization, then ...

Prolonged juvenile hypothyroidism results in a permanent loss in height that is related to the duration of thyroxine deficiency before adequate thyroxine replacement treatment. A 13 year old girl with severe juvenile hypothyroidism was studied prospectively. She had an undetectable serum thyroxine concentration, a height SD score of -6.6 SD, and a bone age of 5.8 years. The enlarged pituitary g...

statement of the problem: a major objective of investigators is to clarify the role of metabolites in achievement of maximum tooth movement with minimal root damage during orthodontic tooth movement (otm). purpose: the aim of this study was to determine the effect of administration of thyroid hormone, prostaglandin e2, and calcium on orthodontic tooth movement and root resorption in rats. mater...

INTRODUCTION Urinary iodine concentrations were analyzed in the morning urine samples of patients with differentiated thyroid cancer (DTC). MATERIAL AND METHODS The analyzed group included 572 DTC patients who were treated with radioiodine or hospitalized for evaluation of radioiodine treatment effects in 2009 at the Institute of Oncology in Gliwice. Ioduria was analyzed by PAMM (Program Agai...

Our experience with the determination of thyroxine (T4) in serum using a homogeneous enzyme immunoassay technique (EMIT, Syva Corp.) is reported. The intra-assay precision of the EMIT Manual Thyroxine Assay was investigated with 2 different calibrator concentrations and showed coefficients of variation varying from 5--2% for thyroxine concentrations of 40 and 120 micrograms/l thyroxine respecti...

An increase in apparent thyroxine values obtained by competitive protein-binding assay on storage of sera is well documented. We find that the major source of this positive bias is probably the unsaturated nonesterified fatty acids. Nonesterified fatty acids cause a positive basis in the competitive protein-binding assay for serum thyroxine because they inhibit the binding of radioactive thyrox...

Objective: The goal of this study was to examine the effect in vivo melatonin (MEL) administration on isolated thoracic aorta rats with thyroxine treatment and its duty aortic response contractile agents, such as potassium chloride (KCl) phenylephrine (PE). In addition, immunohistological alterations were also examined.
 Methods: Experimental groups follows: control group (n= 5), 6), + 6)....

The observation that thyroxine stimulated in vitro protein synthesis in the absence of mitochondria (Carter, W.J., Faas, F.H., and Wynn, J (1971) J. Biol. Chem. 246, 4973-4977) has been disputed on the basis that radioactivity incorporated into protein did not represent peptide synthesis but incorporation of labeled contaminants present in the L-(U-14C) valine precursor (Sokoloff, L., and Rober...

OBJECTIVES The objectives of this study were to determine which serum thyroid hormone test best identifies iatrogenic hypothyroidism in cats that develop azotaemia after radioiodine treatment and to determine which thyroid test best differentiates these azotaemic, hypothyroid cats from azotaemic, radioiodine-treated euthyroid cats, as well as from azotaemic cats with chronic kidney disease and ...