In this article, it is demonstrated that current methods of modelling plasticity as the collective motion of discrete dislocations, such as two-dimensional discrete dislocation plasticity (DDP), are unsuitable for the simulation of very high strain rate processes (106 s−1 or more) such as plastic relaxation during shock loading. Current DDP models treat dislocations quasi-statically, ignoring t...

The advent of high-throughput measurements of gene expression and bioinformatics analysis methods offers new ways to study gene expression patterns. The primary goal of this study was to determine the time sequence for gene expression in a bone subjected to mechanical loading during key periods of the bone-formation process, including expression of matrix-related genes, the appearance of active...

sequence-specific posttranscriptional regulators of gene expression, acting via RNA-induced silencing complexes (RISCs). They are termed small interfering RNAs (siRNAs) and microRNAs (miRNAs). Despite initial discovery from unrelated studies, these RNA classes are related in their biogenesis and assembly into RISC RNA–protein complexes, and are able to regulate gene transcripts negatively in di...

The solution of Higushi’s model for controlled release of drugs is examined when the solubility of the drug in the polymer matrix is a prescribed function of time. A time-dependent solubility results either from an external control or from a change in pH due to the activation of pH immobilized enzymes. The model is described as a one-phase moving boundary problem which cannot be solved exactly....

in this paper, optimal distributed control of the time-dependent navier-stokes equations is considered. the control problem involves the minimization of a measure of the distance between the velocity field and a given target velocity field. a mixed numerical method involving a quasi-newton algorithm, a novel calculation of the gradients and an inhomogeneous navier-stokes solver, to find the opt...

In mandibular edentulous patients, treatment based on immediate loading with rigid splinting in the mandible is well accepted; however, it is cost and time dependent, which sometimes limits this type of rehabilitation. To overcome these problems, the technique of immediate loading using a semirigid splinting extension system has been developed. Its advantages include low cost, technical feasibi...

This paper provides an analytical solution for the time-dependent performance evaluation of truck handling operations at an air cargo terminal. The demand for loading and unloading operations is highly time-dependent and stochastic for two classes of trucks. Two heterogeneous handling facilities with multiple servers are available to handle trucks assuming exponentially distributed processing t...

Abstract—The current study aims to highlight the loading characteristics impact on the time evolution (focusing particularly on long term effects) of the deformation of realized reinforced concrete beams. Namely the tension stiffening code provisions (i.e. within Eurocode 2) are reviewed with a clear intention to reassess their operational value and predicting capacity. In what follows the expe...