Background: The role of mesenchymal stem cell in cellular therapy is the subject of interest for many researchers. The differentiation potential of MSCs and abilities in modulations of the recipient’s immune system makes them important cells in tissue regenerative studies. MSCs by releasing the proinflammatory cytokines play important role in immunomodulatory systems; however the signaling path...

background: periodontal ligament stem cells (pdlscs) are considered as a type of mesenchymal stem cell that is beneficial target for numerous clinical applications in periodontal tissue regeneration therapy. materials and methods: this study examined the effects of dexamethasone (dex) on human pdlscs in vitro. pdlscs obtained from the roots of patient’s teeth were cultured with dex (0.01 μm), a...

although spinal cord injury (sci) is one of the most common injuries after a road accident, there is no definite treatment for it. in this regard, nanotechnology has focused to retrieve damaged tissue function by designing of a biomaterial as a mimicking extracellular matrix to reduce inflammation, scar and lactate dehydrogenase, to fill the cyst and improve the graft integration, cell prolifer...

background  isolation of adipose tissue mesenchymal stem cells (mscs) with current enzymatic methods has some limitations. for example, it is costly and time-consuming and results in a heterogeneous cell population that making compromise proliferation and differentiation of mscs. also, it is accompanied with the increased risk of culture contaminations because of several handling steps.in this ...

Bone diseases such as osteoporosis, delayed or impaired bone healing, and osteoarthritis still represent a social, financial, personal burden for affected patients society. Fully humanized in vitro 3D models of cancellous tissue are needed to develop new treatment strategies meet patient-specific needs. Here, we demonstrate successful cell-sheet-based process optimized mesenchymal stromal cell ...

Background Adipose tissue mesenchymal stem cells (AT-MSCs) are suitable choices in treatment of liver associated diseases. Dimethyl Sulfoxide (DMSO) is an amphipathic molecule with potential of delivering both lipophilic and hydrophilic agents into cells. Few protocols used DMSO for induction of AT-MSCs towards hepatocyte like cells but the effect of DMSO on hepatogenic differentiation were no...