tendon never restores the complete biological and mechanical properties after healing. bone marrow and recently adipose tissue have been used as the sources of mesenchymal stem cells, which have been proven to enhance tendon healing. stromal vascular fraction (svf), derived from adipose tissue by an enzymatic digestion, represents an alternative source of multipotent cells, which undergo differ...

Annulus fibrosus (AF) is the outer tissue of intervertebral disc (IVD) which is a highly specialized element of the spine that provides flexibility and dissipative capacities. When mechanical loads are transmitted along the spine, IVD mainly supports compression and bending stresses. This results in a hydrostatic excessive pressure in the central nucleus pulposus and generates circumferential t...

in this study, physical vapor deposition (pvd) ti-cr-n coatings were deposited at two different temperatures100 and 400ºc on hardened and tempered tool steel substrates. the influence of the applied deposition temperature on the physical and mechanical properties of coatings such as roughness, thickness, phase composition, hardness and young’s modulus were evaluated. phase compositions were stu...

Alterations in tissue hydration that accompany inflammation or chronic remodeling of the Extracellular Matrix (ECM) have significant impact on the biomechanics of vascular tissue in health and disease. Examination of tissue behavior under controlled hydration in vitro could be helpful in better understanding the effects of tissue water content on its mechanical properties where in vivo tissue c...

Prior studies indicated that mechanical loading influences cell turnover and matrix remodeling in tissues, suggesting that mechanical stimuli can play an active role in engineering artificial tissues. While most tissue culture studies focus on influence of uniaxial loading or constraints, effects of multi-axial loading or constraints on tissue development are far from clear. In this study, we e...

Soft Tissue Engineering In article number 2215220, Scott J. Hollister, Michael E. Davis, and co-workers report, 3D printing of a novel architected auxetic with enhanced mechanical biological performance. Specifically, the printed auxetics have high flexibility, permeability, nonlinear deformation behavior as demonstrated through computational, mechanical, analysis. These characteristics provide...

Reliable elasticity parameters describing the behavior of a given material are an important issue in the context of physically-based simulation. In this paper we introduce a method for the determination of the mechanical properties of brain tissue. Elasticity parameters Young's modulus E and Poisson's ratio nu are estimated in an iterative framework coupling a finite element simulation with ima...

due to the existence of fibrous materials such as plastic fragments, the strength anisotropy of municipal solid waste (msw) materials is the main source of differences between their mechanical response in direct shear and triaxial apparatus. as an extension of earlier research on the mechanical behavior of msw using a large traixail apparatus, results presented in shariatmadari et al. [1] and k...

background: autoregulation of blood flow is a marvelous phenomenon balanc- ing blood supply and tissue demand. although many chemically-based explanations for this phenomenon have been proposed and some of them are commonly used today, biomechanical aspects of this phenomenon was neglected. the biomechanical aspect provides insights to us to model vessel diameter changes more precisely and comp...

At present, mechanisms by which specific structural and mechanical properties of the three-dimensional extracellular matrix microenvironment influence cell behavior are not known. Lack of such knowledge precludes formulation of engineered scaffolds or tissue constructs that would deliver specific growth-inductive signals required for improved tissue restoration. This article describes a new mec...