background : in recent years tissue engineering developed to replace or repair damaged tissues using cell and biomaterial. one of the most important fields of tissue engineering is simulation of in vivo micro environment of body tissues. this study aimed to develop culture chamber and cell biomaterial sheet engineering for the reconstruction of cartilage tissue. methods : stainless steel cultur...

The structure of an osteochondral biphasic scaffold is required to mimic native tissue, which owns a calcified layer associated with mechanical and separation function. The two phases of biphasic scaffold should possess efficient integration to provide chondrocytes and osteocytes with an independent living environment. In this study, a novel biphasic scaffold composed of a bony phase, chondral ...

objective: this study examined the in vivo differentiation of mesenchymal stem cells (mscs) into insulin producing cells (ipcs) on electrospun poly-l-lactide acid (plla) scaffolds coated with matricaria chammomila l. (chamomile) oil. materials and methods: in this interventional, experimental study adipose mscs (amscs) were isolated from 12 adult male new zealand white rabbits and characterized...

Several challenges persist when attempting to utilize decellularized tissue as a scaffold for vascular tissue engineering. Namely: poor cell infiltration/migration, excessive culture times associated with repopulating the scaffolds, and the achievement of a quiescent medial layer. In an attempt to create an optimum vascular scaffold, we customized the properties of decellularized porcine caroti...

Tissue damage and disease impose a significant burden on individuals, society, the economy. Current tissue engineering techniques have limitations, improvements are necessary to more effectively repair or regenerate damaged diseased tissues. Hydrogels, type of synthetic scaffold, gained increasing attention in due their mechanical support for cells, customizable characteristics, potential overc...

A review about design, manufacture, and mechanobiology of biodegradable scaffolds for bone tissue engineering is given. First, fundamental aspects about bone tissue engineering and considerations related to scaffold design are established. Second, issues related to scaffold biomaterials and manufacturing processes are discussed. Finally, mechanobiology of bone tissue and computational models de...

BACKGROUND A novel, biodegradable, aliphatic polyurethane scaffold was designed to fulfill an unmet clinical need in the treatment of patients with irreparable partial meniscal lesions. HYPOTHESIS Treatment of irreparable partial meniscal lesions with an acellular polyurethane scaffold supports new tissue ingrowth. STUDY DESIGN Case series; Level of evidence, 4. METHODS Fifty-two patients...

Scaffold fabrication and biocompatibility are crucial for successful bone tissue engineering. Nanometer hydroxyapatite (nHAP) combined with collagen (COL) is frequently utilized as a suitable osseous scaffold material. Furthermore, growth factors, including bone morphogenetic protein‑2 (BMP‑2), are used to enhance the scaffold properties. The present study used blending and freeze‑drying method...