The development of antibodies against infused factor VIII (FVIII) in patients with haemophilia A is a serious complication leading to poorly controlled bleeding and increased morbidity. No treatment has been proven to reduce high titre antibodies in patients who fail immune tolerance induction or are not candidates for it. The Rituximab for the Treatment of Inhibitors in Congenital Hemophilia A...

OBJECTIVES Immune response to cytomegalovirus (CMV) impacts adult chronic disease. This study investigates associations of childhood and adulthood social environment, socioeconomic position (SEP) and social mobility with CMV response in young adults. DESIGN Historical prospective study design. SETTING Subcohort of all 17 003 births to residents of Jerusalem between 1974 and 1976. PARTICIP...

Our understanding of the antigenic evolution of the human influenza virus is chiefly derived from experiments in which serum from influenza infected ferrets is tested against panels of virus isolates in the haemagglutination inhibition (HI) assay. The interpretation of these results has been much aided by the development of antigenic mapping techniques, which suppose that the antigenic distance...

OBJECTIVE The immunomodulatory effect of geranial, geranial acetate, gingerol, and eugenol essential oils were evaluated by studying humoral and cell-mediated immune responses. MATERIALS AND METHOD The essential oils were evaluated for immunomodulatory activity in in vivo studies, using rats as the animal model. The essential oils were tested for hypersensitivity and hemagglutination reaction...

Arylsulphate and sulphotransferase activities were determined during the late larval development of the southern armyworm. Arylsulphatase titre attains a maximum during the moult and is at a minimum between moults. Sulphotransferase titre appeared to follow the inverse course. A possible enzymic regulatory mechanism for insect steroid hormones is discussed.

OBJECTIVE To evaluate the influence of pretreatment streptokinase resistance titre and the concentration of IgG antibodies to streptokinase on the efficacy of thrombolytic drugs containing streptokinase in restoring coronary patency in acute myocardial infarction. DESIGN Comparative observational study. SETTING City general hospital. PATIENTS One hundred and twenty four previously unexpos...

Long-distance, female-produced sex pheromones are widespread among moths. Larval feeding provides most of the nutrients for development of these insects but is not thought to influence the de novo production of the fatty-acid derived compounds used as pheromones by most species. Feeding on plant nectar (sugar) by adult moths is important for increasing female fitness and also for the pollinatio...

INTRODUCTION Pandemic influenza A H1N1 infections occurred worldwide from 2009. Children were particularly vulnerable. Novel vaccines were used during the pandemic. OBJECTIVE To assess the persistence of antibody to H1N1 influenza 1 year after children aged 6 months to 12 years had been immunised with two doses of either a non-adjuvanted whole-virion H1N1 influenza vaccine or an AS03B-adjuvan...

Nacima Baron (NB) : Cher Gilles, le titre de votre ouvrage paru en 2021 aux Editions Alya interpelle les geographes. Il sonne comme un jugement fait. Mais derriere l’expression d’une evidence irrefutable, on decele deux enigmes. La premiere provient fascination pour lieux transport, et notamment l’univers ferroviaire. A ce titre, livre n’est pas coup d’essai (Negre al., 2012). au-dela du magnet...