BACKGROUND The advantages of using simulators in skills training are generally recognized, but simulators are often too expensive for medical schools in developing countries. Cheaper locally-made models (or part-task trainers) could be the answer, especially when teachers are involved in design and production (teacher-made models, TM). METHODS We evaluated the effectiveness of a TM in trainin...

A central feature of the prevailing model for retrovirus fusion is conversion of the transmembrane (TM) subunit from a prehairpin to a hairpin-like structure. The fusion inhibition of many retroviruses, except murine leukemia virus (MLV), with peptides corresponding to interacting regions in the hairpin supports the model. MLV fusion is controlled by isomerization of the intersubunit disulfide ...

Traffic matrix (TM) plays an important role in many network engineering and management tasks. However, the accurate TM estimation is still a challenge because the problem is highly under-constrained. In this paper, we propose a considerably accurate approach, termed as Tomofanout, for the estimation of TM in large-scale IP network using the available link load data, routing matrix and partial d...

Transactional memory (TM) is a promising lockfree technique that offers a high-level abstract parallel programming model for future chip multiprocessor (CMP) systems. Moreover it adapts the popular well established paradigm of transaction, thus providing a general and flexible way of allowing programs to atomically read and modify disparate memory locations as a single operation. In this paper,...

In this paper, we propose a novel translation model (TM) based cross-lingual data selection model for language model (LM) adaptation in statistical machine translation (SMT), from word models to phrase models. Given a source sentence in the translation task, this model directly estimates the probability that a sentence in the target LM training corpus is similar. Compared with the traditional a...

The tympanic membrane (TM) has a key role in transmitting sounds to the inner ear, but a concise description of how the TM performs this function remains elusive. This paper probes TM operation by applying a free field click stimulus to the gerbil ear and exploring the consequent motions of the TM and umbo. Motions of the TM were measured both on radial tracks starting close to the umbo and on ...

The leakage loss due to TM-TE mode coupling of TM-like whispering gallery mode in silicon-on-insulator (SOI) thin-ridge disk resonators is investigated for the first time to the best of our knowledge. We show that the propagation losses of TM-like mode in thin-ridge SOI disk resonators are significantly impacted by the radius of the disk. This behavior is predicted by a simple phenomenological ...

Reconstitution of CMV-specific immunity after transplant remains a primary clinical objective to prevent CMV disease, and adoptive immunotherapy of CMV-specific T cells can be an effective therapeutic approach. Because of viral persistence, most CMV-specific CD8(+) T cells become terminally differentiated effector phenotype CD8(+) T cells (TEFF). A minor subset retains a memory-like phenotype (...

The presenilin (PS) proteins are polytopic integral membrane proteins that are critically involved in the development of Alzheimer's disease. The topography of the PS molecule in the endoplasmic reticulum membrane is widely accepted as exhibiting eight-hydrophobic-transmembrane (8-TM) helices. We have previously provided evidence, however, that the intact PS molecule is also present in the cell...