UNLABELLED Quantitative PET imaging relies on accurate attenuation correction. Recently, there has been growing interest in combining state-of-the-art PET systems with MR imaging in a sequential or fully integrated setup. As CT becomes unavailable for these systems, an alternative approach to the CT-based reconstruction of attenuation coefficients (μ values) at 511 keV must be found. Deriving μ...

Future time-of-flight positron emission tomography (TOF-PET) will be in need of ultrafast scintillation materials, with potential seen cross-luminescence (CL). BaF2, for example, shows a sub-100-ps decay time 300 photons produced per MeV. However, it poses challenges, such as medium radiation length, low photofraction, moderate light yield, and vacuum ultraviolet (VUV) around 200nm. Recent deve...

BACKGROUND The maximum standardized uptake value (SUVmax) is a common clinical parameter for quantification in F18-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT), but it is influenced by image reconstruction. The aim of this study was to analyze the association of SUVmax deviations related to point spread function (PSF) and time-of-flight (TOF) reconstruction w...

BACKGROUND Our aim was to characterize the influence of time-of-flight (TOF) and point spread function (PSF) recovery corrections, as well as ordered subset expectation maximization (OSEM) reconstruction parameters, in 82Rb PET/CT quantification of myocardial blood flow (MBF) and myocardial flow reserve (MFR). Rest and stress list-mode dynamic 82Rb PET acquisition data from 10 patients without ...

Positron emission tomography (PET) is used in the clinic and in vivo small animal research to study molecular processes associated with diseases such as cancer, heart disease, and neurological disorders, and to guide the discovery and development of new treatments. This paper reviews current challenges of advancing PET technology and some of newly developed PET detectors and systems. The paper ...

BACKGROUND Integrated clinical whole-body PET/MR systems were introduced in 2010. In order to bring this technology into clinical usage, it is of great importance to compare the performance with the well-established PET/CT. The aim of this study was to evaluate PET performance, with focus on image quality, on Siemens Biograph mMR (PET/MR) and Siemens Biograph mCT (PET/CT). METHODS A direct qu...

The continuing efforts of investigators to achieve the best physical and clinical performances from PET (positron emission tomography) and related hybrid cameras (PET/CT and PET/MRI) have led to remarkable technical advances in hardware and software. Time of flight (TOF) information measurement, which has been enabled thanks to the invention of fast, heavy crystals and advances in fast light de...