Sir, Urticarias unresponsive to antihistamines are frustrating for both physicians and patients. In severe cases, steroids or cyclosporine may be needed.[1] This retrospective observation highlights the potential of warfarin in managing chronic idiopathic urticaria (CIU). halobetasol ointment (P = 0.005), clobetasol ointment and halobetasol ointment (P = 0.015) and halobetasol cream and halobet...

Background. Lichen sclerosus (LS) is an autoimmune inflammatory skin disease that leads to tissue sclerosis. Actually, the first-line treatment consists of local steroid as clobetasol propionate (CP). Polydeoxyribonucleotide (PDRN) has demonstrated anti-inflammatory effects through the reduction of cytokine production and growth stimulation of fibroblast. Objective. To evaluate the efficacy of ...

AIMS To determine whether the abundance of newly formed collagen in healing surgical wounds correlated with scar severity, and whether topical application of steroid cream reduced new collagen formation in patients who have undergone median sternotomy. METHODS Thirty three patients six weeks after sternotomy, and 12 controls were studied. Scars were photographed, and biopsy specimens from sca...

BACKGROUND Bullous pemphigoid is the most common autoimmune blistering skin disease of the elderly. Because elderly people have low tolerance for standard regimens of oral corticosteroids, we studied whether highly potent topical corticosteroids could decrease mortality while controlling disease. METHODS A total of 341 patients with bullous pemphigoid were enrolled in a randomized, multicente...

n engl j med 368;17 nejm.org april 25, 2013 1635 A73-year-old man who had had plaque psoriasis for more than 20 years on the arms, legs, and scalp presented for consultation on a new rash. He had been using topical steroid creams and shampoos to control occasional psoriatic flares. The patient had undergone acupuncture for lower back pain 2 months before presentation, and shortly thereafter new...

Lichen planus is a chronic, inflammatory, autoimmune disease that affects the skin, oral mucosa, genital mucosa, scalp, and nails. Lichen planus lesions are described using the six P's (planar [flat-topped], purple, polygonal, pruritic, papules, plaques). Onset is usually acute, affecting the flexor surfaces of the wrists, forearms, and legs. The lesions are often covered by lacy, reticular, wh...

Curcumin, a selective phosphorylase kinase inhibitor, is a naturally occurring phytochemical present in turmeric. Curcumin has been confirmed to have anti-inflammatory properties in addition to the ability to decrease the expression of pro-inflammatory cytokines in keratinocytes. The interleukin-23 (IL-23)/IL-17A cytokine axis plays a critical role in the pathogenesis of psoriasis. Here, we rep...

Widespread application of clobetasol propionate resulted in suppression of the hypothalamic pituitary axis in four patients. Three patients showed Cushigoid features and developed symptoms of adrenocortical insufficiency on withdrawal of clobetasol.