نتایج جستجو برای: total chromatin length x
تعداد نتایج: 1659963 فیلتر نتایج به سال:
Fragile X syndrome, a common form of inherited intellectual disability, is caused by loss of the fragile X mental retardation protein FMRP. FMRP is present predominantly in the cytoplasm, where it regulates translation of proteins that are important for synaptic function. We identify FMRP as a chromatin-binding protein that functions in the DNA damage response (DDR). Specifically, we show that ...
For q ∈ (0,1) fixed, we characterize the density functions f of absolutely continuous random variables X > 0 with finite expectation whose respective distribution functions satisfy the so-called (LBS) length-bias scaling property X L = qb X , where b X is a random variable having the distribution function b F (x) = (EX )−1 ∫ x 0 y f y d y. For an absolutely continuous random variable X > 0 with...
Sex-chromosome dosage compensation requires selective identification of X chromatin. How this occurs is not fully understood. We show that small interfering RNA (siRNA) mutations enhance the lethality of Drosophila males deficient in X recognition and partially rescue females that inappropriately dosage-compensate. Our findings are consistent with a role for siRNA in selective recognition of X ...
Aneuploidy as a cause of impaired chromatin silencing and mating-type specification in budding yeast
Aneuploidy and epigenetic alterations have long been associated with carcinogenesis, but it was unknown whether aneuploidy could disrupt the epigenetic states required for cellular differentiation. In this study, we found that ~3% of random aneuploid karyotypes in yeast disrupt the stable inheritance of silenced chromatin during cell proliferation. Karyotype analysis revealed that this phenotyp...
In rodent female mammals, there are two forms of X-inactivation - imprinted and random which take place in extraembryonic and embryonic tissues, respectively. The inactive X-chromosome during random X-inactivation was shown to contain two types of facultative heterochromatin that alternate and do not overlap. However, chromatin structure of the inactive X-chromosome during imprinted X-inactivat...
We report that ligation-mediated PCR (LMPCR) can be used for high-resolution study of metaphase chromosomes, and we discuss the role of metaphase chromatin structure in the preservation of differentiated cell states. The X chromosome-linked human PGK1 (phosphoglycerate kinase 1) promoter region was investigated, and euchromatic active X chromosome (Xa) metaphase chromatin was compared with inte...
We have quantitatively studied the space-time dynamics of mitotic chromosome compaction in cultured amphibian cells. After collecting digital phase-contrast images we have done digital image analysis to study spatial correlations in density. We find a characteristic distance at which the strongest correlations occur, which provides a quantitative measure of the size of patches of dense chromati...
BACKGROUND Prior to chromosome segregation, the mitotic spindle bi-orients and aligns sister chromatids along the metaphase plate. During metaphase, spindle length remains constant, which suggests that spindle forces (inward and outward) are balanced. The contribution of microtubule motors, regulators of microtubule dynamics, and cohesin to spindle stability has been previously studied. In this...
Cytogenetic preparations and Feulgen stain of tumor tissue were applied to the question of the relationship between the sex (X) chromatin body and the X-chromosome constitution of tumor cells. The data revealed that in Case 1, a malignant mesonephroma, the tumor was hyperploid and that there was no loss of the C + X group of chromosomes. Nevertheless, not a single X-chromatin body was encounter...
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