نتایج جستجو برای: toxigenic clostridium difficile

تعداد نتایج: 27741  

2014
Heejung Kim Wan Hee Kim Myungsook Kim Seok Hoon Jeong Kyungwon Lee

We evaluated the new C. DIFF QUIK CHEK COMPLETE (CD COMPLETE; TechLab, USA), which is a rapid membrane enzyme immunoassay that uses a combination of glutamate dehydrogenase (GDH) antigen and toxin A and B detection. A total of 608 consecutive loose stool specimens collected from the patients with suspected Clostridium difficile infection (CDI) from August to December 2012 were subjected to the ...

Journal: :Journal of clinical microbiology 2011
Torbjörn Norén Ingegärd Alriksson Josefin Andersson Thomas Akerlund Magnus Unemo

Compared to the composite gold standard cytotoxin B assay and toxigenic culture, the loop-mediated isothermal amplification (LAMP) test for Clostridium difficile had a sensitivity and specificity of 98%, positive predictive value of 92%, and negative predictive value of >99%. A one-hour turnaround time for the LAMP test provides rapid diagnosis and cost savings.

Journal: :CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 2004
Susan M Poutanen Andrew E Simor

Clostridium difficile is the most important cause of nosocomial diarrhea in adults. Illness may range from mild watery diarrhea to life-threatening colitis. An antecedent disruption of the normal colonic flora followed by exposure to a toxigenic strain of C. difficile are necessary first steps in the pathogenesis of disease. Diagnosis is based primarily on the detection of C. difficile toxin A ...

2017
Meenakshi Singh Chetana Vaishnavi Rakesh Kochhar Safrun Mahmood

BACKGROUND & OBJECTIVES Clostridium difficile is the primary cause of hospital-acquired colitis in patients receiving antibiotics. The pathogenicity of the organism is mainly due to the production of toxins. This study was conducted to investigate the presence of toxigenic C. difficile in the faecal samples of hospitalized patients suspected to have C. difficile infection (CDI) and corroboratin...

2017
Meenakshi Singh Chetana Vaishnavi Safrun Mahmood Rakesh Kochhar

BACKGROUND Clostridium difficile is an important cause of infectious colitis among hospitalized patients across the globe. The pathogenic potential of C. difficile in producing significant morbidity and mortality is mainly due to production of toxins A and B. The outbreaks of C. difficile infection (CDI) are due to changes in the genetic sequences of the organism. There is hardly any molecular ...

2014
Victor R. C. Merino Viviane Nakano Sydney M. Finegold Mario J. Avila-Campos

The presence of gene 16S rRNA and genes encoding toxin A (tcdA), toxin B (tcdB), and binary toxin (cdtA/cdtB) of Clostridium difficile in stool samples from children with (110) and without (150) diarrhea was determined by using a TaqMan system. Fifty-seven (21.9%) out of 260 stool samples harbored the 16S rRNA gene. The genetic profile of tcdA+/tcdB- and cdtA+/cdtB+ was verified in one C. diffi...

Journal: :Journal of infection in developing countries 2016
Diane C Halstead Joan Abid Lynne Sloan Diana Meza Daphne Ramsey-Walker Donna Jane Hata

INTRODUCTION Diarrheal disease due to toxigenic Clostridium difficile (CD) accounts for an increased number of hospitalizations and deaths each year. Published guidelines recommend reflex testing of CD antigen-positive samples to molecular testing or testing samples directly by a molecular assay. This multicenter study was designed to compare the accuracy of two different molecular methods targ...

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