نتایج جستجو برای: tp53 mutation and expression

تعداد نتایج: 16973495  

Journal: :Journal of neurosurgery 2009
Wei-Ying Yue Su-Huan Yu Shi-Guang Zhao Zhong-Ping Chen

OBJECT Astrocytoma may progress rapidly or remain stable for many years. To clarify whether molecular characteristics could be prognostic factors, several cell cycling-associated molecular alterations in the diffuse astrocytoma have been investigated. METHODS Thirty-three patients in whom WHO Grade II astrocytoma had been initially diagnosed were assigned to 1 of 3 groups. Group 1 consisted o...

2015
Ching-Hung Lin I-Chiun Chen Chiun-Sheng Huang Fu-Chang Hu Wen-Hung Kuo Kuan-Ting Kuo Chung-Chieh Wang Pei-Fang Wu Dwan-Ying Chang Ming-Yang Wang Chin-Hao Chang Wei-Wu Chen Yen-Shen Lu Ann-Lii Cheng

IHC4 and PAM50 assays have been shown to provide additional prognostic information for patients with early breast cancer. We evaluated whether incorporating TP53 mutation analysis can further enhance their prognostic accuracy. We examined TP53 mutation and the IHC4 score in tumors of 605 patients diagnosed with stage I-III breast cancer at National Taiwan University Hospital (the NTUH cohort). ...

Background: Mutation in NPM1 gene has been reported to be the most common genetic mutation in de novo acute myeloid leukemia (AML). AML with NPM1 gene mutation usually presents with higher initial leukocyte and blast cell counts and negative CD34 expression. We aimed to investigate the difference of initial leukocyte counts, bone marrow blast cell counts and expression of CD34 among patients wi...

Journal: :Blood 2007
Ken H Young Dennis D Weisenburger Bhavana J Dave Lynette Smith Warren Sanger Javeed Iqbal Elias Campo Jan Delabie Randy D Gascoyne German Ott Lisa Rimsza H Konrad Müller-Hermelink Elaine S Jaffe Andreas Rosenwald Louis M Staudt Wing C Chan Timothy C Greiner

Mutations of the TP53 tumor suppressor gene have been associated with poor survival in some series of diffuse large B-cell lymphoma (DLBCL) but not in other studies. The purpose of this study was to identify the frequency of TP53 alterations (mutations or deletions), characterize the gene expression of mutant/deleted cases, and determine the effects of mutations on survival. In a series of DLBC...

Journal: :Oncology reports 2007
Marcela Aranda Fernando Gonzalez-Nilo Gonzalo Riadi Victor Díaz José Perez Ghyslaine Martel Pierre Hainaut Adriana Mimbacas

The p53 tumor suppressor gene (TP53; OMIM: 191170) plays an important role in tumorigenesis in lung epithelial cells. TP53 encodes a sequence-specific DNA-binding protein that regulates transcription of several genes in response to DNA damage promoting cell cycle arrest, DNA repair or apoptosis. A mutation does not necessarily alter the protein function and since not all altered tumor protein p...

Journal: :The Laryngoscope 2014
Chase M Heaton Megan L Durr Osamu Tetsu Annemieke van Zante Steven J Wang

OBJECTIVES/HYPOTHESIS To determine the incidence and clinical significance of TP53 and CDKN2a somatic mutations in never smokers with oral tongue squamous cell carcinoma (OTSCC). STUDY DESIGN Case series. METHODS Fifty-one paraffin-embedded tumors from never smokers with OTSCC were obtained. p53 and p16 expression was determined by immunohistochemical (IHC) staining. Tumor DNA was amplified...

2002
Anita Langerød Ida R. K. Bukholm André Bregård Per Eystein Lønning Tone Ikdal Andersen Torleiv O. Rognum Gunn Iren Meling Ragnhild A. Lothe Anne-Lise Børresen-Dale

An Arg/Pro polymorphism in codon 72 of the TP53 gene was analyzed in blood samples from 390 breast and 162 colorectal cancer patients previously investigated for TP53 mutations in their tumors. Among the breast cancer cases, 228 were homozygous for the Arg72 allele, of which, 65 (28.5%) also had a TP53 mutation in their tumors. In contrast, of 26 cases that were homozygous for the Pro72 allele,...

Journal: :Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2002
Anita Langerød Ida R K Bukholm André Bregård Per Eystein Lønning Tone Ikdal Andersen Torleiv O Rognum Gunn Iren Meling Ragnhild A Lothe Anne-Lise Børresen-Dale

An Arg/Pro polymorphism in codon 72 of the TP53 gene was analyzed in blood samples from 390 breast and 162 colorectal cancer patients previously investigated for TP53 mutations in their tumors. Among the breast cancer cases, 228 were homozygous for the Arg72 allele, of which, 65 (28.5%) also had a TP53 mutation in their tumors. In contrast, of 26 cases that were homozygous for the Pro72 allele,...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه صنعتی اصفهان - دانشکده ریاضی 1389

one of the most important number sequences in mathematics is fibonacci sequence. fibonacci sequence except for mathematics is applied to other branches of science such as physics and arts. in fact, between anesthetics and this sequence there exists a wonderful relation. fibonacci sequence has an importance characteristic which is the golden number. in this thesis, the golden number is observed ...

2017
Hajime ASADA Masaya TSUBOI James K. CHAMBERS Kazuyuki UCHIDA Hirotaka TOMIYASU Yuko GOTO-KOSHINO Koichi OHNO Hajime TSUJIMOTO

Canine histiocytic sarcoma (HS) is a malignancy originating from the histiocytic cell lineage and characterized by poor response to chemotherapy and short survival time. Mutation of the TP53 gene and its association with poor prognosis has been reported in several canine tumors. However, the mutation of this gene has not been investigated in canine HS. The aim of this study was to examine a TP5...

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