BACKGROUND AND PURPOSE Topiramate (TPM) is a sulfa-derivative monosaccharide that is used mainly for treating epilepsy and preventing migraine. Within the gamut of side effects attributable to this drug, ophthalmologic manifestations are of crucial importance. In this study, for the first time, the aim was to provide a systematic literature review regarding this issue. METHODS For the time pe...

PURPOSE Status epilepticus (SE) is a life-threatening medical condition associated with significant morbidity and mortality that requires urgent medical intervention. Although several agents are available to treat SE, they occasionally fail to abort seizure activity. Topiramate (TPM) was anecdotally reported to be effective in adult patients with refractory SE. In this study, we evaluated the e...

PURPOSE To study the pharmacokinetics of topiramate (TPM) during delivery, lactation, and in the neonate. METHODS TPM concentrations in plasma and breast milk were measured with fluorescence polarization immunoassay (FPIA) in five women with epilepsy treated with TPM during pregnancy and lactation. Blood samples were obtained at delivery from mothers, from the umbilical cord, and from the new...

A new octacyanotungstate(V) based single chain magnet {[(Tpm)Co(DMF)W(CN)8]2[Co(DMF)4]$2DMF}n (1, Tpm 1⁄4 1,1,1-trispyrazoylmethane), with an effective barrier of 39.7(3) cm 1 is reported. The Ising-like magnetic anisotropy of the chain originates from the nearly parallel local orientations of the Co(II) ions with the source of the uniaxial magnetic anisotropy being a trigonal distortion of the...

The Trusted Platform Module (TPM) is a device that can be used to enhance the security of web applications. However, the TPM has to be used in a proper manner in order to benefit from its security properties. A threat model will contribute towards developing a better understanding of how to use the TPM and serve as a reference for future work. In this paper, a web application scenario based on ...

We report a case of a 5-year-old boy with intractable partial seizures who developed a transient hemiparesis, worsening of the electroencephalogram (EEG) and a change in his seizure pattern with increased seizure frequency after receiving topiramate (TPM). Symptoms resolved within a month after TPM was discontinued. Clinicians need to be aware that TPM use may occasionally be associated with fo...

Insufficiently protected mobile devices present an ubiquitous threat. Due to severe hardware constraints, such as limited printed circuit board area, hardware-based security as proposed by the Trusted Computing Group is usually not part of mobile devices, yet. We present the design and implementation of seTPM, a secure element based TPM, utilizing Java Card technology. seTPM establishes trust i...

PURPOSE The aim of this study was to assess factors associated with the use of topiramate (TPM) in refractory status epilepticus (RSE). METHODS We retrospectively reviewed RSE episodes over a 12-year period. Episodes treated with and without TPM were compared in terms of demographics, RSE characteristics, clinical course, and outcome in univariate and multivariate analyses. Subgroups defined ...

Attempts to prepare the mononuclear [(tpm)Ni(II)L(3)](-1) [tpm = tris-(1H-pyrazol-1-yl)methane and L = thio-cyanate] anion yielded the methanol-solvated salt, [(tpm)(2)Ni(II)][(tpm)Ni(II)(NCS)(3)](2)·2CH(3)OH or [Ni(C(10)H(10)N(6))(2)][Ni(NCS)(3)(C(10)H(10)N(6))](2)·2CH(3)OH. The asymmetric unit consists of half a centrosymmetric bis-[tris-(1H-pyrazol-1-yl)methane]-nickel(II) cation and an octa...