Pancreatic cancer is highly malignant with limited therapy and a poor prognosis. TRAIL-activating therapy has been promising, however, clinical trials have shown resistance and limited responses of pancreatic cancers. We investigated the effects of calmodulin(CaM) antagonists, trifluoperazine(TFP) and tamoxifen(TMX), on TRA-8-induced apoptosis and tumorigenesis of TRA-8-resistant pancreatic can...

Transradial arterial access (TRA) has been employed for transcatheter coronary procedures for more than 25 years, with numerous studies demonstrating improved patient safety as compared with transfemoral arterial access. However, TRA remains underused by the interventional radiology and vascular surgery communities. Advantages of TRA over transfemoral arterial access include easier accomplishme...

To date, a range of exercises have been used to improve the function of the lumbar multifidus (LM) and transversus abdominis (TrA) muscles in people with low back pain, but uncertainty remains as to what exactly constitutes meaningful LM and TrA training. We examined the effects of exercising with a new device which combines weight-bearing, an unstable base of support (BOS) (feet), an upright p...

We propose a simple and robust automatic strategy for managing SDH/SONET and/or ATM virtual paths in real time to handle slow tra c variations. It consists of on-line measurements of o ered tra cs followed by the design and possible implementation of a new virtual path network in a repeated cycle. Methods and parameters for tra c measurements and network updating are studied and optimised to ac...

PCN188 SubCutaNeouS VS INtraVeNouS admINIStratIoN of traStuzumab IN Her2+ breaSt CaNCer PatIeNtS: a maCedoNIaN CoSt-mINImIzatIoN aNalySIS Nestorovska A1, Naumoska Z1, Grozdanova A1, Stoleski D2, Ivanovska A2, Risteski M3, Vasev N3, Ismaili I3, Stefanovski P4, Dimovski A1, Suturkova L1, Sterjev Z5 1ISPOR Republic of Macedonia regional chapter, Skopje, Macedonia, 2Roche Macedonia, DOOEL, Skopje, ...

We present our research on acquiring domain knowledge related to urban vehicular tra c by means of interaction with experts. Such knowledge is needed in knowledge discovery and data mining for approximation of complex vague concepts from the road tra c. According to perception based computing paradigm, this can be done by construction of hierarchical classi ers supported with expert knowledge. ...

In C. elegans, the zinc-finger protein TRA-1A is thought to be the final arbiter of somatic sexual identity. We show that fog-3, which is required for germ cells to become sperm rather than oocytes, is a target of TRA-1A. First, northern analyses and RT-PCR experiments indicate that expression of fog-3 is controlled by tra-1. Second, studies of double mutants show that this control could be dir...

Cellular Automaton and Kalman Filter D. Emeliyanov1;2 I. Gorbounov2;3 I. Kisel4;5 1 Institute of Control S ien es, Profsoyuznaya ul., 65, Mos ow, 117806 Russia 2 Deuts hes Elektronen-Syn hrotron DESY, Notkestrasse 85, D-22607 Hamburg, Germany 3 University of Siegen, Department of Physi s, D-57068 Siegen, Germany 4 Joint Institute for Nu lear Resear h, Dubna, Mos ow region, 141980 Russia 5 Max-P...

In wild-type Caenorhabditis elegans there are two sexes, self-fertilizing hermaphrodites (XX) and males (XO). To investigate the role of tra-1 in controlling sex determination in germline tissue, we have examined germline phenotypes of nine tra-1 loss-of-function (lf) mutations. Previous work has shown that tra-1 is needed for female somatic development as the nongonadal soma of tra-1(lf) XX mu...

Female differentiation of Drosophila germ cells is induced by cell-nonautonomous signals generated in the gonadal soma that work with germ-cell-autonomous signals determined by germ-cell X chromosome dose. Generation of the nonautonomous feminizing signals was known to involve female-specific protein encoded by the master sex-determination gene Sex-lethal (Sxl) acting on its switch-gene target ...