نتایج جستجو برای: traf1

تعداد نتایج: 238  

Journal: :Mechanisms of Development 2001
Anette Preiss Bernd Johannes Anja C. Nagel Dieter Maier Nathalie Peters Harald Wajant

TNF-receptor associated factors (TRAFs) comprise a family of adaptor proteins that act as downstream signal transducers of the TNF receptor superfamily and the Toll/interleukin-1 receptor family. The mammalian TRAFs 2, 5 and 6 are known to activate JNK- and NF-kappaB signaling pathways, whereas the function of the other three mammalian family members, TRAF 1, 3 and 4 is less well characterized....

Journal: :Gaceta medica de Mexico 2016
Ana Karen Rodríguez-Elías Karina Maldonado-Murillo Luis Fernando López-Mendoza Julián Ramírez-Bello

Rheumatoid arthritis is a chronic inflammatory autoimmune disease that affects approximately 0.5-1% of the general population and leads to chronic synovial inflammation, destruction of cartilage and bone, and disability. The heritability of rheumatoid arthritis has been estimated to be about 60%, while the contribution of HLA to heritability has been estimated to be 11-37%. Other genes, such as...

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