Qualitative research in primary care deepens understanding of phenomena such as health, illness and health care encounters. Many qualitative studies collect audio or video data (e.g. recordings of interviews, focus groups or talk in consultation), and these are usually transcribed into written form for closer study. Transcribing appears to be a straightforward technical task, but in fact involv...

RNA polymerase I (Pol I) is a 14-subunit enzyme that solely synthesizes pre-ribosomal RNA. Recently, the crystal structure of apo Pol I gave unprecedented insight into its molecular architecture. Here, we present three cryo-EM structures of elongating Pol I, two at 4.0 Å and one at 4.6 Å resolution, and a Pol I open complex at 3.8 Å resolution. Two modules in Pol I mediate the narrowing of the ...

This paper describes incorporating discriminative features from a multi layer perceptron (MLP) into a state-of-the-art Arabic broadcast data transcription system based on cepstral features. The MLP features are based on a recently proposed Bottle-Neck architecture with long-term warped LPTRAP speech representation at the input. It is shown that the previously reported improvements on a developm...

Neocortical layer VI modulates the thalamocortical transfer of information and has a significant impact on sensory processing. This function implicates local γ-aminobutyric acidergic (GABAergic) interneurons that have only been partly described at the present time. Here, we characterized 85 layer VI GABAergic interneurons in acute slices of mouse somatosensory barrel cortex, using whole-cell cu...

Double-stranded RNA viruses in the family Reoviridae are capable of transcribing and capping nascent mRNA within an icosahedral viral capsid that remains intact throughout repeated transcription cycles. However, how the highly coordinated mRNA transcription and capping process is facilitated by viral capsid proteins is still unknown. Cypovirus provides a good model system for studying the mRNA ...

We had introduced a set of 2D melodic units to transcribe Carnatic music previously, and we now provide some illustrative examples using real pitch tracks to further our discussion on this topic.

Automatic music transcription aims to transcribe musical performances into music notation. However, existing transcription systems that have been described in research papers typically focus on multi-F0 estimation from audio and only output notes in absolute terms, showing frequency and absolute time (a piano-roll representation), but not in musical terms, with spelling distinctions (e.g., A[ v...

Mismatched crowdsourcing derives speech transcriptions using crowd workers unfamiliar with the language being spoken. This approach has been demonstrated for isolated word transcription tasks, but never yet for continuous speech. In this work, we demonstrate mismatched crowdsourcing of continuous speech with a word error rate of under 45% in a large-vocabulary transcription task of short speech...