objective: hypoxia-inducible factor (hif)-1 plays an essential role in the body’s response to low oxygen concentrations and regulates expression of several genes implicated in homeostasis, vascularization, anaerobic metabolism as well as immunological responses. increased levels of hif-1α are associated with increased proliferation and more aggressive breast tumor development. lactobacilli have...

Introduction: E2F is a group of genes that encodes family transcription factors in higher eukaryotes. Although emerging evidence indicates E2Fs are implicated various cancer types, the diverse expression patterns and prognostic values SKCM have yet to be elucidated. The purpose this study was enhance our knowledge concerning role patients.. Methods: GEPIA, Human Protein Atlas, TIMER, cBioPortal...

As an evolutionarily conserved pathway, Hippo signaling not only plays a key role in embryonic development, but also regulates the initiation and progression of cancer. The upstream factors regulating pathway are complex, including cell–cell contact, cell–extracellular matrix membrane receptor–ligand binding, cytoskeletal tension. In response to these mechanical or soluble cues, core kinases ac...

Rap2a, a member of Ras family small GTPases, plays key role in growth and development. So far, no Rap2a homolog has been discovered crustaceans. Herein, from shrimp Litopenaeus vannamei , named LvRap2a, was cloned identified. LvRap2a showed high level sequence conservation to other homologs different species. found be abundantly expressed hemocytes, muscle, hepatopancreas intestine tissues. Imp...

The Neurospora crassa GUL-1 is part of the COT-1 pathway, which plays key roles in regulating polar hyphal growth and cell wall remodeling. We show that a bona fide RNA-binding protein (RBP) can associate with 828 “core” mRNA species. When integrity (CWI) challenged, expression over 25% genomic RNA species are modulated (2,628 mRNAs, including mRNA). binds mRNAs genes related to translation, re...

glaucoma, a group of multifactor ocular diseases, is the second leading cause of blindness worldwide. primary open angle (poa) is the most common type of glaucoma, characterized by progressive optic nerve degeneration. numerous genes and proteins have been revealed to be associated with poag, but the pathologic mechanisms of the disease are still poorly understood. proteomics, the collective st...

BACKGROUND This study aimed to identify key genes contributing to pathological complete response (pCR) to chemotherapy by mRNA sequencing (RNA-seq). MATERIAL AND METHODS RNA was extracted from the frozen biopsy tissue of patients with pathological complete response and patients with non-pathological complete response. Sequencing was performed on the HiSeq2000 platform. Differentially expressed ...