objective: in this paper, we have introduced topoisomerase inhibitors, mechanism of action and types of them. dna topoisomerases are ubiquitous enzymes that catalyze essential enzymes to solve the topological problems accompanying key nuclear processes such as dna replication, transcription, repair and chromatin assembly by introducing temporary single or double strand breaks in the dna. result...

background: pomegranate fruit (punica granatum l.) is a rich source of anthocyanin pigments resulting in vibrant colours and anti-oxidant contents. although the intensity and pattern of anthocyanin biosynthesis in fruit are strongly influenced by r2r3-myb transcription factors, little is known about the regulation and role of myb in anthocyanin pathway of pomegranate.objectives: the present stu...

Introduction Modernity has reached a dead end. The optimism in which the modern world was conceived and nurtured has been replaced by a thoroughgoing skepticism that denies the possibility of making meaningful truth claims, especially when those claims bear on morality and religion. The irony is that this has occurred as we have become increasingly confident of scientific utterances. Thus, as o...

This paper explores the decisions involved in a digital stemmatology project. Traditionally, transcription, collation, and creation of stemma have been processes linked to edition texts. However, on its own can provide valuable insight further understanding literary works since it sheds light their production process. The research textual tradition Troilus Criseyde offers possibility reconsider...

human immunodeficiency virus (hiv) transactivator tat is a potent activator of both viral and cellu lar genes. tat has also been implicated in the development of aids-related malignancy. here, we show that tat physically and functionally is able to sequester the cell cycle check point protein p53. this sequestration results in non-functional promoter activity of cyclin-dependent kinase/cyclin i...

one of the bases for the development of an iranian theory of international relations is the intellectual and practical traditions found in the course of iran’s history. the ways in which iranians have perceived and understood world politics, however, have not been monolithic and have changed in the course of time due to particular historical circumstances inside iran as well as at the regional ...

this article reviews the commentary tradition around the metaphysics of avicenna’s shifā’ as it evolved in the lands that belonged to avicenna’s own cultural horizon, most of all in iran. from this overview it emerges that this tradition is characterized by a keen interest  in textual criticism and a solid philosophical grasp of avicenna’s metaphysical doctrines. this interest is reflected in t...

<p><strong>Abstract: </strong>This article aims to explain the Tabot tradition and its cultural construction with Bengkulu people as a minority group. The experienced kind of acculturation process in which two or more cultures met made contact. Using Berry’s theory qualitative approach ethnographic methods, this study resulted finding that Tabut from between different religiou...