Background: Human tauopathy brain injections into the mouse induce development of tau aggregates, which spread to functionally connected regions; however, features this neurotoxicity remain unclear. One reason may be short observational periods because previous studies mostly used mutated-tau transgenic mice and needed complete study before these developed neurofibrillary tangles. Objective: To...

Analysis of a new transgenic mouse model with β-cell-specific overexpression of human betacellulin Work performed under supervision of Dr. During the preparation of this thesis the following supplementary activities were pursued: 1. Participation in a research project leading to the publication: KLONISCH T., negative modulator of body and organ weights in transgenic mice. FEBS Abstract title: P...

Successful experiments involving the production of transgenic mice by pronuclear microinjection are currently limited by low efficiency of random transgene integration into the mouse genome. Furthermore, not all transgenic mice express integrated transgenes, or in other words are effective as functional transgenic mice expressing the desired product of the transgene, thus allowing accomplishmen...