Incorporating phenotypic screening as a key strategy enhances predictivity and translatability of drug discovery efforts. Cellular imaging serves as a "phenotypic anchor" to identify important toxicologic pathology that encompasses an array of underlying mechanisms, thus provides an effective means to reduce drug development failures due to insufficient safety. This mini-review highlights the l...

This paper aims to explore the translatability of drag terminology used in popular reality competition RuPaul’s Drag Race (RPDR), from English into Macedonian. There are two hypotheses on which study is based: 1) The people who use terms find it more natural them as borrowings (i.e. their original form (in English)) and 2) If were be taken Macedonian, they would often adapted undergo naturalisa...

Mitochondria have long been known to be the gatekeepers of cell fate. This is particularly so in the response to acute ischaemia-reperfusion injury (IRI). Following an acute episode of sustained myocardial ischaemia, the opening of the mitochondrial permeability transition pore (MPTP) in the first few minutes of reperfusion, mediates cell death. Preventing MPTP opening at the onset of reperfusi...

In this article, we revisit the view update framework by Bancilhon and Spyratos in a setting with constraints expressed in first-order logic. We explicitly consider constraints on both the database and the view schemas, along with inter-schema constraints that implicitly define the view mappings. Using the notion of logical definability we give a constructive characterisation of views, their in...