نتایج جستجو برای: transmission blocking vaccine
تعداد نتایج: 397418 فیلتر نتایج به سال:
We describe the design and report baseline results of a cluster-randomized intervention to determine the importance of bovines for Schistosoma japonicum transmission in southern China. The study involves four matched village pairs in Hunan and Jiangxi Provinces, with a village within each pair randomly selected as intervention (human and bovine praziquantel treatment) or control (human praziqua...
Plasmodium P25 and P28 Surface Proteins: Potential Transmission-Blocking Vaccines Ajay K. Saxena,* Yimin Wu, and David N. Garboczi School of Life Sciences, Jawaharlal Nehru University, New Mehrauli Road, New Delhi 110067, India; Malaria Vaccine Development Branch, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), 5640 Fishers Lane, Rockville, Ma...
Hemozoin (malaria pigment) has been implicated in the modulation of immune responses during malaria infection. This study was designed to evaluate the effect of purified hemozoin on the in vitro activation of myeloid dendritic cells. Our study also revealed that in addition to enhancing the maturation of dendritic cells, hemozoin also greatly promotes immunoglobulin G2a antibody responses when ...
The worldwide decline over the last decade in the number of clinical cases of malaria does not mean an end to the universal problem of malaria pathogenesis in those afflicted by infection. Resistance to drugs, higher risk of disease relapse and failure to maintain effective memory of the pathogen in the absence of persistent exposure result in the repeated failure of anti-malarial treatments. T...
BACKGROUND The sexual stages of Plasmodium falciparum are responsible for the spread of the parasite in malaria endemic areas. The cysteine-rich Pfs48/45 protein, exposed on the surface of sexual stages, is one of the most advanced antigens for inclusion into a vaccine that will block transmission. However, clinical Pfs48/45 sub-unit vaccine development has been hampered by the inability to pro...
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