During the course of a clinical trial, subjects may experience treatment failure. For ethical reasons, it is necessary to administer rescue medications for such subjects. However, the rescue medications may bias the set of response measurements. This bias is of particular concern if a subject has been randomized to the placebo group, and the rescue medications improve the subject’s condition. T...

Penicillinase-producing strains of Neisseria gonorrhoeae (PPNG) were detected in nine out of 27 (3.2%) treatment failures in 310 cases of acute gonococcal urethritis in men in Lusaka, Zambia. Minimum inhibitory concentrations of penicillin for 17.2% of 233 gonococcal isolates were less than or equal to 0.05 microgram/ml, for 38.2% between 0.125 and 0.25 microgram/ml, and for 46.6% greater than ...

Article history: Received 24 January 2009 Accepted 19 July 2010 Available online 27 July 2010

Integrative bargaining, also known as “problem-solving,” “value-creating,” or “win-win” negotiation, is the centerpiece of normative negotiation scholarship and negotiation teaching. It has held this position at least since the publication of “Getting to Yes” by Fisher and Ury in 1981, and perhaps since the publication of “A Behavioral Theory of Labor Negotiations” by Walton and McKersie in 196...

PURPOSE To assess clinical antimicrobial efficacy results obtained with besifloxacin ophthalmic suspension, 0.6%, administered three times a day (TID) for 5 days, integrated across three clinical trials of bacterial conjunctivitis and to investigate any microbiological eradication failures. METHODS Clinical microbiological eradication data from three randomized, double-masked, parallel group ...