BACKGROUND There is as yet no effective and safe treatment for vitiligo. One percent pimecrolimus cream, a topical calcineurin inhibitor, has been tried for the treatment of vitiligo, with its therapeutic efficacy having mostly been reported in non-segmental vitiligo. However, questions about the therapeutic efficacy of 1% pimecrolimus cream have remained unanswered regarding segmental vitiligo...

Correspondence: Nanny van Geel Department of Dermatology, De Pintelaan 185, 9000 Ghent, Belgium Tel +32 9 332 22 87 Fax +32 9 332 49 96 Email [email protected] Abstract: Vitiligo is an acquired cutaneous disorder of pigmentation, with an incidence of 0.5% to 2% worldwide. There are three major hypotheses for the pathogenesis of vitiligo that are not exclusive of each other: biochemical/cyt...

Vitiligo is a common autoimmune disease of the skin that results in disfiguring white spots. There are no Food and Drug Administration (FDA)-approved treatments, and current treatments are time-consuming, expensive, and of low efficacy. We sought to identify new treatments for vitiligo, and first considered repurposed medications because of the availability of safety data and expedited regulato...

  Vitiligo is a common idiopathic acquired cutaneous pigmentary disorder resulting in depigmented skin. A wide variety of therapeutic modalities have been employed for its treatment, but none of them are satisfactory, in this study we have tested the effect of 5- fluorouracil 5FU on 54 patients with documented vitiligo in Kerman city. The following treatments were performed on three selected v...

Vitiligo, is a skin disorder, in which the loses its pigment due to loss of melanocytes. The exact cause still under research but disorder linked autoimmune disease, oxidative stress, genetics and environmental variables. disease being progressive nature often spreads all over body. Globally, Vitiligo affects nearly about 0.5% 1% people. In 2012, most recent approved classification for was give...

Childhood vitiligo differs from adult-onset vitiligo for several features including increased incidence of the segmental variant, higher prevalence of halo nevi, and more common family history for autoimmune diseases and atopic diathesis. The major differential diagnoses are the postinflammatory hypomelanoses for nonsegmental vitiligo and nevus depigmentosus for segmental vitiligo. From a thera...

There is a current lack of consensus regarding methods of assessment of vitiligo. Recently, the Vitiligo Area Scoring Index (VASI) and the Vitiligo European Task Force (VETF) were proposed to offer more accurate measures of disease severity indexes and treatment evaluation criteria. It would make sense to combine the VASI with the VETF system. We proposed an original scale for treatment evaluat...

Received: December 14, 2016 Revised: February 01, 2017 Accepted: February 03, 2017 Abstract: Background: Vitiligo is the most common acquired pigmentary disorder in the world. Due to alterations in physical appearance, vitiligo is a psychologically devastating disease. Although treatment options exist, a cure for this disease has yet to be discovered. Of recent interest in vitiligo is the relat...

Vol. 27, No. 1, 2015 107 Received March 12, 2014, Revised April 4, 2014, Accepted for publication April 9, 2014 Corresponding author: Ozge Mine Orenay, Department of Dermatology, Faculty of Medicine, Turgut Ozal University, Alparslan Turkes Caddesi No. 57, Ankara 06510, Turkey. Tel: +90-312-203-5257, Fax: +90-312-221-3670, E-mail: [email protected] This is an Open Access article distributed ...