Background: Despite the effective pre- and post-exposure treatments, at least 60,000 deaths from rabies occur worldwide every year. Post-exposure treatment is considered as one of the most significant measures for preventing human deaths in exposed individuals. The 2-1-1 rabies post-exposure treatment schedule known as Zagreb regimen is an abbreviated immunization plan in which a tissue cultu...

OBJECTIVES To determine the frequency of adverse effects related to the use of the tuberculosis treatment regimen designated Regimen I and the need for regimen alterations due to these effects. METHODS A retrospective analysis of 329 medical charts of patients who were treated with Regimen I and discharged after cure between March 2000 and April 2006 was carried out at the Tuberculosis Outpat...

Background: Helicobacter pylori (H.pylori) infection causes multiple upper gastrointestinal diseases but optimal therapeutic regimen which can eradicate infection in all the cases has not yet been defined. This study was designed to evaluate the efficacy of triple levofloxacin-based versus clarithromycin-based therapy. Methods: In this open-label randomized clinical trial study 120 patients ...

high-dose extended-interval dosage (hded) regimen of aminoglycosides is now considered as the standard dosage strategy in sepsis. although safety and efficacy of this dosing regimen is well studied, but new experiments show increased the risk of resistance development associated with %t>mic less than 60% of the dosing interval following extended interval dosing. moreover, limited information is...

extensively drug-resistant tuberculosis (xdr-tb) is a new challenge for tuberculosis control programs. lack of effective drugs and high rate of failure in treatment and mortality is a major threat for public health. treatment of this serious infection needs well-designed individualized dosage regimen and powerful national tb program. in this review we will describe the xdr-tb definition and its...

multidrug-resistant (mdr) and extensively drug-resistant (xdr) tuberculosis (tb) are increasing globally. treatment options for these patients are very limited. although treatment of these patients with standardized regimen is associated with high mortality and morbidity, rational usage of new drugs might be promising. in this study we will review epidemiology of xdr-tb and tdr-tb in iran and t...

There have been significant developments in effective human immunodeficiency virus treatment since the first antiretroviral was approved. A number of people living with not able to maintain viral suppression on oral therapy. long-acting monthly injectable regimen consisting cabotegravir and rilpivirine has approved for individuals who are virally suppressed. This is a good option those struggle...

abstract   backgrounds: pott's disease is a rare form of extrapulmonary tuberculosis, and presents with several clinical patterns. delay in diagnosis and management may cause serious complications. we conducted a retrospective study between 1991- 2006 to evaluate clinical presentation, radiologic and laboratory findings, and therapeutic approaches to spinal tuberculosis.   methods: we reviewed ...

 ABSTRACT Background: Triple therapy with a proton pump inhibitor, clarithromycin and amoxicillin and quadruple therapy with a proton pump inhibitor, bismuth citrate, metronidazole and amoxicillin have been proposed in Maastricht 2000 as the optimal treatment of Helicobacter pylori infection. We aimed to compare these two regimens in Iranian pediatric patients. Methods: A randomized clinical tr...