Introduction: During the last decade, the trend in drug discovery has increased the number of active pharmaceutical ingredients (APIs) that exhibit high lipophilicity and poor water solubility, also associated with poor dissolution characteristics (Vogt et al., 2008). Dissolution rate in the gastrointestinal tract is the rate limiting factor for the absorption of many of these drugs, which ther...

This work presents related areas of research, types of data collections that are visualized, technical aspects of generating visualizations, and evaluation methodologies. Existing methods are structured and explained from the aspect of visualization process. Successful applications are noted and some future trends in the field are anticipated. Keywords— Information Visualization, Visual Analyti...

We report here the discovery of a new aromatic hydrocarbon superconductor, Sm-doped chrysene, with Tc ∼ 5 K, and compare its behavior with those measured in the full series of Sm-doped [n]phenacene superconductors, with n = 3, 4, 5, thus determining the trend of Tc as a function of the number of fused benzene rings and for an odd or even number of units.

A major trend in the current information society is personalization, which is considered a key business enabler for mobile services because the mobile device is a personal assistant that offers unique opportunities such as real-time adaptation of services to a dynamic user environment. To offer personalized services in a consistent manner and to speed up the development of such services, we pre...

Proteomics enables understanding the composition, structure, function and interactions of the entire protein complement of a cell, a tissue, or an organism under exactly defined conditions. Some factors such as stress or drug effects will change the protein pattern and cause the present or absence of a protein or gradual variation in abundances. Changes in the proteome provide a snapshot of the...

PURPOSE The workshop explored the current problems, needs, and potential usefulness of existing methods of discovery of new therapies to treat epilepsy patients. Resistance to medical therapy (pharmacoresistance) and the development of epilepsy (epileptogenesis) are recognized as two of the major problems in epilepsy treatment today. At the same time, there is growing awareness that the develop...

helicobacter pylori :28 µg/ml).   (h. pylori) infection leads to different clinical and pathological outcomes in humans, including chronic gastritis, peptic ulcer disease and gastric neoplasia and even gastric cancer and its eradiation dependst upon multi-drug therapy. the most effective therapy is still unknown and prompts people to make great efforts to find better and more modern natural or ...

expert discovery is a quest in search of finding an answer to a question: “who is the best expert of a specific subject in a particular domain within peculiar array of parameters?” expert with domain knowledge in any field is crucial for consulting in industry, academia and scientific community. aim of this study is to address the issues for expert-finding task in real-world community. collabor...