BACKGROUND A high-fat diet has been recommended for the treatment of patients with mitochondrial myopathy due to complex I (NADH dehydrogenase) deficiency (CID). OBJECTIVE This study evaluated the effects of intravenous infusion of isoenergetic amounts of triacylglycerol or glucose on substrate oxidation, glycolytic carbohydrate metabolism, and exercise endurance time and energy state of musc...

Abstract Traditional methods used to determine oil purity like fatty acids and sterols are time consuming chemically wasteful; standards that utilize these require a large set of samples cover natural variables establish upper and/or lower limits for each compound. Due this, it can be challenging the newer products on market, avocado oil, when have not yet been fully developed. Triacylglycerol ...

Although triacylglycerol stores play the critical role in an organism's ability to withstand fuel deprivation and are strongly associated with such disorders as diabetes, obesity, and atherosclerotic heart disease, information concerning the enzymes of triacylglycerol synthesis, their regulation by hormones, nutrients, and physiological conditions, their mechanisms of action, and the roles of s...

Cell-surface F1F0-ATP synthase was involved in the cell signaling mediating various biological functions. Recently, we found that cell-surface F1F0-ATP synthase plays a role on intracellular triacylglycerol accumulation in adipocytes, and yet, the underlying mechanisms remained largely unknown. In this study, we investigated the role of extracellular ATP on the intracellular triacylglycerol acc...

The binary phase behavior of triacylglycerol (TAG) mixtures constituted by PPP (tripalmitin) and either POP (1,3-dipalmitoyl-2-oleoyl-glycerol), OPO (1,3-dioleoyl-2-palmitoyl-glycerol), or MCPOP/OP...

The control of chylomicron output by the intestine is a complex process whose outlines have only recently come into focus. In this review we will cover aspects of chylomicron formation and prechylomicron vesicle generation that elucidate potential control points. Substrate (dietary fatty acids and monoacylglycerols) availability is directly related to the output rate of chylomicrons. These subs...

BACKGROUND Diacylglycerol is a natural component of edible oils that has metabolic characteristics that are distinct from those of triacylglycerol. OBJECTIVE We assessed the efficacy of an oil containing mainly 1,3-diacylglycerol in reducing body weight and fat mass when incorporated into a reduced-energy diet. DESIGN The study was a randomized, double-blind, parallel intervention trial tha...

This study compares the effects of glucose and fatty acid on hepatic lipid synthesis and apolipoprotein (apo) B secretion. To do so, varying concentrations of either glucose or oleic acid were added to the medium in which HepG2 cells were being incubated. Intracellular triacylglycerol and cholesteryl ester synthesis and secretion were measured by addition of radioisotopic tracers and by determi...

Current dietary recommendations for fatty acid intakes aimed at reducing the prevalence of CHD are largely based on the cholesterol hypothesis and on the well-established effects of specific fatty acid classes on fasting total cholesterol, LDL and HDL concentrations (Department of Health, 199 1, 1994). Increasing recognition of the potential atherogenic and thrombogenic consequences of elevated...

BACKGROUND Dietary fat quality may influence skeletal muscle lipid processing and fat accumulation, thereby modulating insulin sensitivity. OBJECTIVE The objective was to examine the acute effects of meals with various fatty acid (FA) compositions on skeletal muscle FA processing and postprandial insulin sensitivity in obese, insulin-resistant men. DESIGN In a single-blind, randomized, cros...