a series of fluoroquinolone derivatives holding triazolidindione moieties have been synthesized and proved to be cytotoxic agents in vitro particularly against cancer cell lines (sknmc, mcf7, a2780-cp, sw48, a549, kb, ht-29, hepg 2 ). the cytotoxic activity was assessed using mtt colorimetric assay. our compounds had less cytotoxicity than doxorubicin in all studied cell lines.

Compounds containing two N-heterocyclic olefin (NHO) moieties connected by a 1,1′-ferrocenylene linker are described, which represent new class of ferrocene-based bidentate ligands. They contain three redox-active groups, viz. the ferrocene unit and NHO moieties, can be oxidised consecutively according to their cyclovoltammetric behaviour.

Zwitterions and polyoxometalates (POMs) are two kinds of functional moieties with very different properties for applications in different fields. We have developed an effective strategy to successfully immobilize these two different moieties into the frameworks of porous hybrid materials, in which the POM units act as templates and photoactive moieties. These hybrid materials demonstrate remark...

Reaction of mercuric acetate with an imidazolium-linked cyclophane incorporating 2,6-phenolic moieties results in formation of an interesting new N-heterocyclic carbene (NHC) complex of mercury. The new complex is cationic and binuclear, incorporating two mercury centres and two bis(NHC) ligands, each mercury atom being bound by two NHC moieties and two phenol/phenoxy moieties. Forms of the com...

BACKGROUND Occupational exposure to airborne low molecular weight chemicals, like trimellitic anhydride (TMA), can result in occupational asthma. Alveolar macrophages (AMs) are among the first cells to encounter these inhaled compounds and were previously shown to influence TMA-induced asthma-like symptoms in the Brown Norway rat. TMA is a hapten that will bind to endogenous proteins upon entra...

In this study, Santa Barbara Amorphous (SBA-15) mesoporous silica has been functionalized with aminopropyl groups that were converted to propargyl-bearing moieties through the reaction with propargyl bromide. The material then underwent an efficient Cu(I)-catalyzed azide alkyne click reaction with sodium azide in order to obtain the corresponding triazole products. The covalent modification of ...