نتایج جستجو برای: triple hypoxia syndrome
تعداد نتایج: 721107 فیلتر نتایج به سال:
BACKGROUND Pulmonary hypertension (PH) is a lethal syndrome associated with the pathogenic remodeling of the pulmonary vasculature and the emergence of apoptosis-resistant cells. Apoptosis repressor with caspase recruitment domain (ARC) is an inhibitor of multiple forms of cell death known to be abundantly expressed in striated muscle. We show for the first time that ARC is expressed in arteria...
Insulin resistance is often associated with obstructive sleep apnoea syndrome (OSAS) and could contribute to cardiovascular risk in OSAS. Sleep loss and intermittent hypoxia could contribute to the pathogenesis of the metabolic alterations associated with obesity, a common feature of OSAS. The biology of the adipocyte is being increasingly studied, and it has been found that hypoxia negatively ...
New Oral Anticoagulants in Acute Coronary Syndrome: Is There Any Advantage Over Existing Treatments?
BACKGROUND After an acute coronary syndrome, dual antiplatelet therapy with clopidogrel plus aspirin is still a standard of care, but several new approaches have been investigated. OBJECTIVES The present study re-examined the studies published thus far on this topic to evaluate the effectiveness of dual antiplatelet therapy in comparison to some of these new approaches (mainly, ticagrelor + a...
Mirror syndrome, also called Ballantyne’s or triple edema syndrome, was described in 1982 by John Ballantyne as a combination ofmaternal edema, fetal and placental hydrops. This syndrome is a complication of fetal hydrops inwhich the maternal edema virtuallymirrors the edema of the fetus. The incidence is not clear since it is a rare disease, often underdiagnosed.1–3 Fetal hydrops of any etiolo...
Experimental data suggest therapeutic advantage from selective disruption of the hypoxia response. We recently found that the proteasome inhibitor bortezomib decreases tumor carbonic anhydrase IX (CAIX) expression in colon cancer patients and herein report a companion laboratory study to test if this effect was the result of hypoxia-inducible factor (HIF) inhibition. Human cervical (SiHa and Me...
BACKGROUND Ischemic preconditioning (IPC) and postconditioning (POC) are well documented to trigger cardioprotection against ischemia/reperfusion (I/R) injury, but the effect oftheir both co-application remains unclear in human heart. The present study sought to assessthe co-application of IPC and POC on fragments of human myocardium in vitro. METHODS Muscular trabeculae of the human right at...
Objective: To explore the mechanism by which macrophages secrete CCL22 to promote metastasis of triple-negative breast cancer under hypoxic conditions. Methods: 20 ng/mL mass concentration phorbol 12-myristate 13-acetate (PMA) cell culture medium, 4?,6-diamidino-2-phenylindole (DAPI), dimethyl sulfoxide (DMSO), trypsin digestion solution, CCL18 Kit , Interleukin (IL)-10 Kit, CCL17 TRIzolTM Reag...
There is increasing evidence that intermittent hypoxia plays a role in the development of cardiovascular risk in obstructive sleep apnoea syndrome (OSAS) through the activation of inflammatory pathways. The development of translational models of intermittent hypoxia has allowed investigation of its role in the activation of inflammatory mechanisms and promotion of cardiovascular disease in OSAS...
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