Licorice (roots and stolons of Glycyrrhiza plants, Leguminosae) is a well-known natural sweetener, and its sweet constituent is an oleanane-type triterpene saponin, glycyrrhizin. Cultured cells of G. glabra do not produce glycyrrhizin, but produce two structurally different triterpenoid constituents, betulinic acid and soyasaponins. Both glycyrrhizin and soyasaponins are oleanane-type triterpen...

Microbial production of plant derived, biologically active compounds has the potential to provide economic and ecologic alternatives to existing low productive, plant-based processes. Current production of the pharmacologically active cyclic triterpenoid betulinic acid is realized by extraction from the bark of plane tree or birch. Here, we reengineered the reported betulinic acid pathway into ...

Five previously undescribed triterpenoid saponins (1-5), along with eight known ones (6-13), were isolated from the whole plants of Anemone rivularis var. flore-minore. Their structures were clarified by extensive spectroscopic data and chemical evidence. For the first time, the lupane-type saponins (3 and 12) were reported from the Anemone genus. The anti-proliferative activity of all isolated...

The sea cucumber (phylum Echinodermata) body wall is the first line of defense and is well known for its production of secondary metabolites; including vitamins and triterpenoid glycoside saponins that have important ecological functions and potential benefits to human health. The genes involved in the various biosynthetic pathways are unknown. To gain insight into these pathways in an echinode...

This report describes the isolation and partial purification of novel triterpenoid saponins [Fraction 35 (F035)] and two pure biologically active derivatives (termed avicins D and G) from Acacia victoriae, an Australian desert tree of the Leguminosae family. F035 and the avicins markedly inhibited the growth of several tumor cell lines with minimum growth inhibition in human foreskin fibroblast...

There is growing interest in development of natural products as anti-cancer and chemopreventive agents. Many triterpenoids have been proved as potential agents for chemoprevention and therapy of breast cancer. Ginsenosides from ginseng, which mostly belong to dammarane-type triterpenoids, have gained great attention for their anti-breast cancer activity with diverse mechanisms. However, studies...

Penelitian ini bertujuan untuk menentukan aktifitas penghambatan kerja enzim ?-glucosidase oleh ekstrak air dan etanol dari daun, batang akar kayu kuning ( Arcangelisia flava ) secara in vitro. Aktifitas a-glukosidase diukur pada panjang gelombang 400 nm berdasarkan jumlah p-nitrofenol yang dihasilkan. Daya hambat dilihat nilai IC 50 . Dari sebesar 195,161; 138,9881 48,68632 mg/mL 365,8793; 123...

Air-dried, milled leaves of Knoxia corymbosa (220 gm) were extracted repeatedly with dichloromethane. After removal of solvent in vacuo, the CH2Cl2-solvent residue was fractionated by using hexane and ethyl acetate solvents. After fractionation, all fractions are submitted for NMR spectroscopy. Out of all fractions interesting fractions are subjected to column chromatography, so that we isolate...