1 Division of Hepatology and Gene Therapy. Center for Applied Medical Research (CIMA), Pamplona, Spain. 2 Small Animal Imaging Research Unit, CIMA-CUN, Pamplona, Spain. 3 Amsterdam Molecular Therapeutics, BV, Amsterdam, The Netherlands; 4 Morphology and Imaging Unit, CIMA, Pamplona, 5 Division of Neuroscience, CIMA, Pamplona, 6 Department of Radiology, University Clinic of Navarra, UNAV, Pamplo...

first-principle calculations were carried out to investigate the adsorption of co over cun nanoclusters. the structural, spectroscopic and electronic properties like optimized geometries, homo (highest occupied molecular orbital) and lumo (lowest unoccupied molecular orbital) energy levels, binding energy, adsorption energy, vibrational frequency and density of states (doss) of the pure cun nan...

The urban spatial structure is a key feature of the distribution social and economic resources. an agglomeration abstract relationship expression urbanization. Urban agglomerations develop for multiple reasons, including planning natural evolution. To date, most research related to has been based on single data source, which limitation. This aims propose identification method via complex networ...

The twelve-membered tetraazamacrocyclic ligand L1 bears an appended lipoic acid unit, whose disulphide ring is an efficient grafting moiety for the surface of gold nanostars (GNS). The GNS that were used featured a localized surface plasmon resonance (LSPR) absorption at ∼800 nm, i.e. in the near infrared (NIR). We investigated different approaches for coating them with the Cu(2+) complex of L1...

Abstract C 18 H 12 Br 2 CuN 4 O , monoclinic, P 1 / c (no. 14), a = 11.5165(11) Å, b 5.4369(5) 14.4872(14) V 873.52(14) Å 3 Z 2, R gt ( F ) 0.0232, wR ref 0.0559, T 200 K.

Mitochondrial disorders can cause an array of neuroophthalmologic manifestations such as ptosis, external ophthalmoparesis, nystagmus, pigmentary retinopathy, and optic neuropathy.1 The m.3243A G point mutation in the mitochondrial genome, an alanine-toguanine transition at position 3243 of mitochondrial DNA, in the MT-TL1 gene that encodes the tRNALeu (UUR), commonly presents as an encephalopa...

An adenine-to-guanine mutation at nucleotide position (np) 3243 in the mitochondrial tRNALeu(UUR) gene is closely associated with various clinical phenotypes of diabetes mellitus. Because the mutation creates a new restriction site for the restriction enzyme ApaI, the mutation is usually detected and quantified by ApaI cleavage of the PCR products including np 3243. The sensitivity of the conve...