OBJECTIVES We aim to illustrate the multimodal imaging spectrum of hepatic involvement in tuberculosis (TB). Whilst disseminated tuberculosis on imaging typically manifests as multiple small nodular lesions scattered in the liver parenchyma, isolated hepatic tuberculosis remains a rare and intriguing entity. METHODS Indubitably, imaging is the mainstay for detection of tubercular hepatic lesi...

Background Tuberculosis (TB) is a disease that produces several million deaths annually. With the appearance of multi drug resistant microbial strains of Mycobacterium tuberculosis, innovations in TB drug discovery and evolving strategies to bring new agents with best performance is an essential investigation. Taking this into account, there is a pressing need to develop new and more effective ...

Objective: Tuberculosis, known in short as TB, is considered to be a global crisis caused by Myco bacterium tuberculosis, and which continues serious challenge public health world wide especially the developing countries. A problem related tuberculosis development of drug resistant strains.
 Methods: Present study describes synthesis eight novel derivatives 1,3,4-thiadiazole vitro evaluati...

Joining the global fight against Tuberculosis, world's most deadly infectious disease, herein we present design and synthesis of novel isatin-nicotinohydrazide hybrids (5a–m 9a–c) as promising anti-tubercular antibacterial agents. The activity target was evaluated drug-susceptible M. tuberculosis strain (ATCC 27294) where 5d, 5g 5h were found to be potent INH with MIC = 0.24 µg/mL, also Isoniaz...

There has been considerable interest in the development of new anti tubercular agents particularly against multidrug resistance and extensively drug resistant strain of tuberculosis because mycobacterium species have developed resistant against currently used drugs. The currently use antitubercular drugs having toxic effect and long period of therapeutic treatment. Therefore, many researchers h...