Mycobacterium tuberculosis, the causative agent of tuberculosis, is a major cause of morbidity and mortality worldwide. However, an effective vaccine for M. tuberculosis is lacking. We panned a phage display library using monoclonal antibodies against M. tuberculosis liporabinomannan (LAM), an important component of the M. tuberculosis cell wall, and identified two peptide sequences, HSFKWLDSPR...

BACKGROUND An understanding of the trends in tuberculosis incidence, prevalence, and mortality is crucial to tracking of the success of tuberculosis control programmes and identification of remaining challenges. We assessed trends in the fatal and non-fatal burden of tuberculosis over the past 25 years for 195 countries and territories. METHODS We analysed 10 691 site-years of vital registrat...

conclusions clinicians should be aware that tbm might have unusual presentations. early diagnosis and treatment are essential to decrease mortality and morbidity such as irreversible neurological deficits. case presentation a 66-year-old diabetic man was admitted to our hospital. he complained of prolonged left otalgia and headache. antibiotic therapy was started for mastoiditis and otitis medi...

The objective was to analyze the trend in tuberculosis mortality in Paraná from 1998 to 2012, according to healthcare macro-region-al, gender and age. Ecological study of time series data with the system of the Unified System Mortality Information Health (SIM/SUS). Trend analysis of standardized mortality rates was performed by linear regression segmented identifying the points with the change ...

Introduction: Tuberculosis and diabetes mellitus both are the two most important public health problems inIndia. India is presently having highest burden of tuberculosis second mellitusglobally. Many studies have shown to poorer treatment outcome in diabetic patients.Aim: To evaluate difference antitubercular regimens patients compared tonon-diabetic patients.Materials Methods: Active presentin...

Worldwide, tuberculosis is the main infectious cause of death among adults, with most of these deaths occurring in developing countries [1–3]. Many tuberculosis-associated deaths may be preventable by adequate chemotherapy. In developed countries, despite a decline in the overall tuberculosis-associated mortality, the risk of death of patients with tuberculosis has increased, with an upward shi...

BACKGROUND The association between body mass index and mortality in patients with tuberculosis has not been extensively studied, and the existing evidence is inconsistent. This study aimed to investigate the impact of body mass index on timing of death in patients with tuberculosis. METHODS All Taiwanese adults with tuberculosis in Taipei, Taiwan, were included in a retrospective cohort study...

BACKGROUND AND OBJECTIVE Studies focusing on pulmonary tuberculosis in advanced age (≥80 years) are lacking. This study aimed to explore treatment delay, outcomes and their predictors in this group. METHODS Adult (≥20 years) patients with pulmonary tuberculosis were identified from the National Health Insurance Research Database of Taiwan from 2004 to 2009. Treatment completion and mortality ...

OBJECTIVE To evaluate the medical records of patients with pulmonary tuberculosis in order to determine the inhospital mortality rate. MATERIALS AND METHODS Medical records of 22,651 patients with pulmonary tuberculosis admitted to Gulhane Military Medical Academia, Camlica Chest Diseases Hospital, Istanbul, Turkey from 1977 to 1999 were examined. RESULTS Of the 22,651 patients, 133 (0.58%)...

Background & Aims: Tuberculosis is one of the most important causes of mortality in the world and if it is not treated, 50 – 65% of patients would die in five years. Chest X-ray has an important role in the diagnosis of TB and early diagnosis and treatment prevent tuberculosis transmission. In this study we evaluated radiologic manifestations of patients with smear positive pulmonary tubercu...