PURPOSE Androgen ablation therapy leads to mild regression or stabilization of prostate cancer, followed by progression to the fatal androgen-independent state. Whereas androgen ablation diminishes tumor angiogenesis by suppressing vascular endothelial growth factor (VEGF) production, androgen-independent disease is marked by androgen-independent VEGF expression. We examined combined androgen a...

BACKGROUND Radiofrequency ablation (RFA), a thermal coagulation technique, has been used for ablation of primary and secondary liver tumors. METHODS Over a 24-month period, 41 patients, including 20 with hepatocellular cancer (HCC), 14 with liver metastases from colorectal tumors and 7 with metastases from other tumors, underwent RFA in our institution. Ablation was done using intra-operative...

Pech: There are indeed distinct limitations of thermal ablation such as radiofrequency ablation (RFA), despite RFA being the most frequently used local ablation tool available. However, in many cases anatomical locations with adjacent thermosensitive structures or the size of a specific lesion represent strong limitations in daily routine, requiring more efforts in the development of non-therma...

PURPOSE The use of oncolytic herpes simplex virus type 1 is a promising stategy for cancer treatment. We constructed herpes simplex virus type 1 vector G47Delta by deleting the alpha47 gene and the promoter region of US11 from G207. We now report studies demonstrating the potential of G47Delta as a therapeutic modality for prostate cancer in combination with androgen ablation. EXPERIMENTAL DE...

Background: Percutaneous tumor ablation has become an important nonsurgical treatment for primary and secondary malignant hepatic tumors[1]. A critical part of the tumor ablation is intra-treatment monitoring to determine whether an adequate treatment is achieved[2]. A recent study looking at long term efficacy of radiofrequency ablation in treatment of liver tumors over a 6 year period demonst...

BACKGROUND Intraoperative evaluation of successful pancreatic tumor ablation using irreversible electroporation (IRE) is difficult secondary to lack of visual confirmation. The IRE generator provides feedback by reporting current (amperage), which can be used to calculate changes in tumor tissue resistance. The purpose of the study was to determine if resistance can be used to predict successfu...

OBJECTIVE The objective of our study was to review radiofrequency ablation of 100 renal tumors and lessons learned with respect to electrode approach, effects on collecting system, bowel proximity, and patterns of residual disease. MATERIALS AND METHODS Over 6 years, 100 renal tumors in 85 patients underwent radiofrequency ablation. Images were reviewed to determine the following: effect of i...

Introduction High-intensity focused ultrasound (HIFU) is an innovative noninvasive procedure for local ablation of different benign and malignant tumors. Preliminary data animal studies suggest ablation-associated immune response after HIFU that induced by cell necrosis release intracellular components. The aim this study to evaluate if a HIFU-induced early sterile inflammatory reaction initiat...

Figure 4. Axial gadolinium-enhanced T1-weighted magnetic resonance imaging of a 63-year-old man with hepatocellular carcinoma 1month after treatment with IRE. Note the zone of ablation (arrows) extending beyond the unenhanced tumor (#). Asterisk indicates contracted gallbladder. Arrowheads (˄) indicate perfusional changes adjacent to the zone of ablation and not tumor recurrence. Young et al ’ ...