B7-H4 is a recently identified B7 family member. We previously showed that ovarian tumor and associated macrophages expressed B7-H4; tumor B7-H4+ macrophages and CD4+CD25+FOXP3+ regulatory T cells (Treg cells) suppressed tumor-associated antigen-specific T-cell immunity. To determine the pathologic relationship between B7-H4, macrophages, and Treg cells in the tumor environment, in addition to ...

Macrophages in the tumor microenvironment engulf apoptotic cells through myeloid-epithelial-reproductive tyrosine kinase (MerTK)-mediated efferocytosis, and further polarized towards an M2 phenotype. However, regulatory mechanism of efferocytosis polarization tumor-associated macrophages (TAMs) remains unclear. Here, we performed single-cell RNA sequencing patients with melanoma identified a po...

Distinct tumor microenvironment forms in each progression step of cancer and has diverse capacities to induce both adverse and beneficial consequences for tumorigenesis. It is now known that immune cells can be activated to favor tumor growth and progression, most probably influenced by the tumor microenvironment. Tumor-associated macrophages and tumor-associated neutrophils can exert protumora...

Abstract Macrophages are key members of the innate immune system involved in phagocytosis, antigen presentation and other immunological functions. also important players response to tumor. Their polarization states determine role that they play tumor microenvironment (TME) generally regarded as M1-like M2-like associated macrophages (TAMs). Subsequently, TME influences how function environment....

This study investigates whether and to what extent cyclooxygenase type-2 (COX-2) and inducible nitric oxide-synthase (iNOS), both known to have an immunosuppressive effect, are expressed in human ovarian tumors. Because COX-2 and iNOS can be expressed by activated macrophages, the presence of tumor-associated macrophages and the expression of COX-2 and iNOS by these tumor-associated macrophages...