It has been shown in several instances that the antibody response to antigens of certain types may be greatly modified by the incorporation of staphylococcus toxin in the immunizing material. Under such conditions of combined immunization the antibodies produced to the major antigen are increased in amount and, in some cases at least, they seem to exhibit qualitative properties not usually enco...

background: androgen receptors (ar) play an important role in proliferation of cancerous prostatic cells and prevention of apoptotic signaling. current drugs cannot inhibit the activity of these receptors very well. establishment of appropriate animal models is essential for discovery of new drugs of target therapy in hormone dependent prostate cancer. materials and methods: standard prostatic ...

We have generated a mouse strain lacking protein kinase C (PKC) to evaluate its significance in epithelial organization and tumor formation. The PKC -deficient mice exhibited increased susceptibility to tumor formation in two-stage skin carcinogenesis by single application of 7,12dimethylbenz(a)anthracene (DMBA) for tumor initiation and repeated applications of 12-O-tetradecanoylphorbol-13-acet...

We have generated a mouse strain lacking protein kinase C (PKC) to evaluate its significance in epithelial organization and tumor formation. The PKC -deficient mice exhibited increased susceptibility to tumor formation in two-stage skin carcinogenesis by single application of 7,12dimethylbenz(a)anthracene (DMBA) for tumor initiation and repeated applications of 12-O-tetradecanoylphorbol-13-acet...

We have generated a mouse strain lacking protein kinase C (PKC) eta to evaluate its significance in epithelial organization and tumor formation. The PKCeta-deficient mice exhibited increased susceptibility to tumor formation in two-stage skin carcinogenesis by single application of 7,12-dimethylbenz(a)anthracene (DMBA) for tumor initiation and repeated applications of 12-O-tetradecanoylphorbol-...

Metastasis is the leading cause of cancer-associated death but has been difficult to study because it involves a series of rare, stochastic events. To capture these events, we developed a sensitive method to tag and track pancreatic epithelial cells in a mouse model of pancreatic cancer. Tagged cells invaded and entered the bloodstream unexpectedly early, before frank malignancy could be detect...

Adalimumab and other tumor necrosis factor-α inhibitors have been shown in the recent years to successfully treat sarcoidosis refractory to systemic corticosteroids and other agents.  However, there have been an increasing number of cases of sarcoidosis paradoxically induced by these agents.  It is hypothesized that this is due to the disruption of the fine balance of cytokines involved in gran...