نتایج جستجو برای: tumor immunity
تعداد نتایج: 502249 فیلتر نتایج به سال:
Background: The use of dendritic cells (DCs) as a cellular adjuvant provides a promis-ing approach in immunotherapy of cancer. It has been demonstrated that Listeria mono-cytogenes activated DCs pulsed ex vivo with tumor antigens trigger a systemic Th1-biased specific immune response and a single dose of this vaccine will cause a consider-able anti tumor immunity. Objective: The present study w...
It is unclear whether PD-L1 on tumor cells is sufficient for tumor immune evasion or simply correlates with an inflamed tumor microenvironment. We used three mouse tumor models sensitive to PD-1 blockade to evaluate the significance of PD-L1 on tumor versus nontumor cells. PD-L1 on nontumor cells is critical for inhibiting antitumor immunity in B16 melanoma and a genetically engineered melanoma...
Self-antigens, in the form of differentiation antigens, are commonly recognized by the immune system on melanoma and other cancers. We have shown previously that active immunization of mice against the melanocyte differentiation antigen, a tyrosinase-related protein (TRP) gp75(TRP-1) (the brown locus protein) expressed by melanomas, could induce tumor immunity and autoimmunity manifested as dep...
Abstract Dendritic cells (DCs) are essential players in the anti-tumor immunity, which often found dysfunctional tumor microenvironment. Impairing DC antigen processing and presentation, subverts T cell priming, is one of primary mechanisms by escape immune surveillance. However, cellular factors regulating presentation DCs how render DCs’ priming capacity not fully understood. We revealed a po...
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