The presence of tumor-specific microRNAs reflects tissue of origin and tumor stage. We show that the absence of miRNAs likewise can be used to determine tumor origin (miR-155) and proliferation state because tumor suppressor miRNAs (miR-222/221, let-7 family) were significantly down-regulated in primary effusion lymphoma (PEL) and in Kaposi sarcoma (KS), an endothelial cell tumor. PEL and KS ar...

Cervical cancer is a disease characterized by the growth of abnormal cells in cervical tissue. mostly caused Human Papillomavirus (HPV) types 16 and 18. The role genetic factors development malignancy mediated presence mutation HPV oncogene, especially oncogenes E6 E7. Oncogenic proteins E7 initiate dysregulation cellular proliferation apoptotic mechanisms targeting tumor suppressor proteins, s...

The p53 tumor suppressor is frequently mutated in various types of cancer. Majority mutations are missense mutations, which results not only loss the suppressive activity (loss function), but also acquirement unexpected oncogenic activities, referred to as gain function (GOF). Although stability and accumulation wild-type (wtp53) mutant (mutp53) proteins crucial exhibit respectively, underlying...

Transducer of ERBB2.1 (TOB1) is a tumor-suppressor protein, which functions as a negative regulator of the receptor tyrosine-kinase ERBB2. As most of the other tumor suppressor proteins, TOB1 is inactivated in many human cancers. Homozygous deletion of TOB1 in mice is reported to be responsible for cancer development in the lung, liver, and lymph node, whereas the ectopic overexpression of TOB1...

Cissampelos owariensis is a medicinal plant with wide range of therapeutic uses. In this study, the objective was to further assess its antiproliferative potential using cell proliferation and tumor suppressor markers. Solvent extraction C. leaves done methanol. Twenty (20) male albino Wistar rats were randomly divided into four groups 1–4 (n=5) respectively administered methanolic extracts at ...

The dynamic alterations in the cytoskeletal components actin and intermediate, etc. filaments are required for cell invasion migration. cytoskeleton is a highly structure that governed by delicate balance of filament formation disassembly. To controlling activities key epithelial mesenchymal transition (EMT) could be viable solution to metastasis. Bioinformatics technologies also allow research...

p53, a tumor suppressor and a transcription factor, binds DNA in a sequence-specific manner. In more than half of human cancers, p53 has been found to be mutated with the loss of DNA-binding ability. In this review, we focus on the sensitive detection of interaction of tumor suppressor p53 with double-stranded DNA bearing the consensus sequence and proteins, such as monoclonal antibodies recogn...

Abstract The tumor-suppressor protein RB acts as a transcription repressor via interaction of its pocket domain with an LXCXE motif in histone deacetylase (HDAC) proteins such HDAC1. Here, we demonstrate that HDAC5 deficient for the interacts both RB-N (via FXXXV motif) and RB-C segments, interactions are diminished by phosphorylation serine-249/threonine-252 threonine-821. was frequently downr...

Although evidence has suggested that the serine/threonine protein phosphatase 2A (PP2A) might be a tumor suppressor protein, it has been difficult to pin down its role in tumor suppression because it acts in a wide variety of signaling pathways. Recent findings, including work in this issue by Junttila et al. (2007), provide convincing evidence that suppression of PP2A activity cooperates with ...

Objective This study aimed to clarify whether Krüppel like Factor 11 (KLF11) acts as an oncogene or a tumor-suppressor in BC.