We previously reported that low doses of interleukin-1 strongly inhibited in vitro development of the hepatic stages of Plasmodium falciparum and P. yoelii. Among several hypotheses, we considered the role of C-reactive protein (CRP), a major acute-phase reactant whose concentration increases markedly in infectious disorders. We demonstrated that human hepatocytes cultured in the presence of in...

Inflammation was induced in rats by the subcutaneous injection of turpentine. Microsomes were prepared from the livers between 2 and 72 h after injection. Mannose and glucose incorporation into mannosyl and glucosyl dolichyl monophosphate was increased 2-fold over saline-injected controls 24 h after induction of inflammation. Synthesis of glycosylated dolichyl pyrophosphoryl oligosaccharides wa...

The aim of this study was to set up a chemometric procedure using near infrared spectra acquired with low-cost handheld spectrometer (SCiO), quantify the main chemical components maritime pine (Pinus pinaster) resin, in view SCiO as quality control tool for tapping industry. This carried out on samples resin harvested during summer 2018, Biscarosse, France. Spectral data were collected both an ...

The need for reducing fossil fuel consumption and greenhouse gas (GHG) emissions in internal combustion engines has raised the opportunity use of renewable energy sources. For progressive replacement fuels like diesel, those derived from sustainable management forest resources may be a good option. In Portugal, pine trees (pinus pinaster) are among most widely cultivated tree species. Turpentin...

The relationship between intensity of inflammatory stimulation and production of α(2)-macroglobulin (α2M) and α(1)-acid glycoprotein (AAG) in rats was investigated. Sprague-Dawley rats were injected with turpentine oil at doses of 0.05, 0.2 or 0.4 mL/rat. Serum levels of α2M, interleukin (IL)-6 and cytokine-induced neutrophil chemoattractant-1 (CINC-1) were measured by enzyme-linked immunosorbe...

To determine the cell of origin of C-reactive protein (CRP) and to cast light on the mechanisms leading to the acute phase response, we used an immunoenzymatic technique to visualize this protein in livers from rabbits at intervals after intramuscular injection of turpentine. CRP was detected only in hepatocytes. 8 h after turpentine injection, CRP was demonstrated in occasional periportal hepa...

Kozak, Wieslaw, and Anna Kozak. Selected Contribution: Differential role of nitric oxide synthase isoforms in fever of different etiologies: studies using Nos gene-deficient mice. J Appl Physiol 94: 2534–2544, 2003. First published January 31, 2003; 10.1152/japplphysiol.01042.2002.—Male C57BL/6J mice deficient in nitric oxide synthase (NOS) genes (knockout) and control (wild-type) mice were imp...