نتایج جستجو برای: two superfamily
تعداد نتایج: 2447936 فیلتر نتایج به سال:
Triadic subgraph analysis reveals the structural features in power networks based on higher-order connectivity patterns. Power have a unique triad significance profile (TSP) of five unidirectional triadic subgraphs comparison with scale-free, small-world and random networks. Notably, closure has highest Thus, TSP can serve as identifier to differentiate from other complex form network superfami...
Objectives. This study was performed to find changes in the plasma cytokine profile of neuroresuscitation patients with ventilator-associated pneumonia, and search for prognostic markers effectiveness antibacterial treatment pneumonia. Materials methods. A two-center clinical study, that included 73 aged 19 82 years neurosurgical neurological pathology signs pneumonia (VAP) conducted. On 1st 3r...
For the first time fish RNases have been isolated and characterized. Their functional and structural properties indicate that they belong to the RNase A superfamily (or tetrapod RNase superfamily), now more appropriately described as the vertebrate RNase superfamily. Our findings suggest why previously repeated efforts to isolate RNases from fish tissues have met with no success; fish RNases ha...
Flap endonuclease (FEN1), essential for DNA replication and repair, removes RNA and DNA 5' flaps. FEN1 5' nuclease superfamily members acting in nucleotide excision repair (XPG), mismatch repair (EXO1), and homologous recombination (GEN1) paradoxically incise structurally distinct bubbles, ends, or Holliday junctions, respectively. Here, structural and functional analyses of human FEN1:DNA comp...
Catalytic promiscuity can facilitate evolution of enzyme functions-a multifunctional catalyst may act as a springboard for efficient functional adaptation. We test the effect of single mutations on multiple activities in two groups of promiscuous AP superfamily members to probe this hypothesis. We quantify the effect of site-saturating mutagenesis of an analogous, nucleophile-flanking residue i...
BLyS and APRIL are two members of the TNF superfamily that are secreted by activated myeloid cells and have costimulatory activity on B cells. BLyS and APRIL share two receptors, TACI and BCMA, whereas a third receptor, BAFF-R, specifically binds BLyS. Both BLyS and APRIL have been described as homotrimeric molecules, a feature common to members of the TNF superfamily. In this study, we show th...
The superfamily Portunoidea including extinct lineages is herein evaluated via cladistic analysis of adult morphological characters and traditional systematics. Nearly every fossil species has been examined via type material, or if this was not possible, through illustrations and original descriptions. The analyses indicate that the superfamily is much more diverse at the family level than has ...
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