In a previous work, we described the possible relationship between a defect of purine-cytosine permease and the acquisition of a cross-resistance to the antifungal combination flucytosine (5FC) and fluconazole (FLC) in Candida lusitaniae (T. Noël, F. François, P. Paumard, C. Chastin, D. Brethes, and J. Villard, Antimicrob. Agents Chemother. 47:1275-1284, 2003). Using degenerate PCR and chromoso...

Human respiratory syncytial virus (RSV) is the most important viral agent of serious pediatric respiratory-tract disease worldwide. A vaccine or generally effective antiviral drug is not yet available. We designed new live attenuated RSV vaccine candidates by codon-pair deoptimization (CPD). Specifically, viral ORFs were recoded by rearranging existing synonymous codons to increase the content ...

Peritumoral injection of recombinant human interleukin 1 beta (IL-1 beta) in mice transplanted subcutaneously with Friend erythroleukemia cells (FLC) resulted in a marked increase in survival time and inhibition of metastatic tumor growth in liver and spleen. In contract, IL-2 treatment alone did not significantly inhibit the development of FLC metastases. A synergistic antitumor effect was obs...

To evaluate the role of root-synthesized ABA in regulating growth and stomatal behaviour under well-watered conditions, isogenic wild-type (WT) and ABA-deficient flacca (flc) tomato (Solanum lycopersicum) were reciprocally and self-grafted just below the cotyledonary node. Since flc scions had lower leaf water potentials due to higher transpiration rates, a subset of all graft combinations was ...

Immunoglobulin free light chains (FLCs) form part of the middle molecule group of uremic toxins. Accumulation of FLCs has been observed in patients with chronic kidney disease (CKD). The aim of the present study was to measure FLC levels in patients at different CKD stages and to assess putative associations between FLC levels on one hand and biochemical/clinical parameters and mortality on the...

In vitro time-kill studies and a rabbit model of endocarditis and pyelonephritis were used to define the impact that the order of exposure of Candida albicans to fluconazole (FLC) and amphotericin B (AMB), as sequential and combination therapies, had on the susceptibility of C. albicans to AMB and on the outcome. The contribution of FLC-induced resistance to AMB for C. albicans also was assesse...

In this paper, we present a modeling and implementation of new control schemes for an isolated photovoltaic (PV) using a fuzzy logic controller (FLC). The PV system is connected to a load through a DC-DC boost converter. The FLC controller provides the appropriate duty cycle (D) to the DC-DC converter for the PV system to generate maximum power. Using FLC controller block in MATLABTM/Simulink e...

In this chapter, a proportional-integral derivative (PID)-type fuzzy logic controller (FLC) is proposed for a discrete-time system in order to track a desired trajectory generated using the flatness property. In order to improve the performance of the proposed controller, genetic algorithm (GA) based on minimizing the integral of the squared error (ISE) is used for tuning the input and output P...

A comparative study on performance in terms of transient time response specifications for position control of a separately excited DC Servomotor using Fuzzy logic control on PD strategy and general PD control strategy is done. Fuzzy Logic Controller (FLC) based on PD strategy is designed for both the inference mechanismsMamdani type and Takagi-Sugeno type. Robustness test for both the controlle...

This paper reviews the literature on control of 2-DOF robot manipulator using fuzzy logic control (FLC). Different schemes of FLC laws are considered here. These are PID control, sliding mode control (SMC), and adaptive control. Importance of each control techniques with its advantages and disadvantages is discussed here. It is highlighted that the robustness of the system has improved consider...