We recently reported the design, synthesis and biological actions of a novel chimeric natriuretic peptide (NP) fusing the 22-amino acid (AA) sequence of mature C-type natriuretic peptide (CNP), a member of the NP family that is highly conserved among species, with the 15-AA C-terminus of Dendroaspis natriuretic peptide (DNP) that was isolated from the venom of the eastern green mamba snake (Den...

BACKGROUND Myocardial dysfunction is a complication associated with a poor prognosis in septic patients. A biomarker of cardiac function providing prognostic information is of paramount interest. OBJECTIVE We sought to determine the value of B-type natriuretic peptide in patients with severe sepsis/septic shock. METHODS We performed a prospective study in patients with severe sepsis/septic ...

The B-type natriuretic peptides; B-type natriuretic peptide and N-terminal pro-B-type natriuretic peptide, are increasing being used as biomarkers for the diagnosis, management and prognostication of cardiac failure, but their application in the peri-operative period is unclear. This review examines the current understanding of the role of B-type natriuretic peptides in both the operative and n...

This study reports the cardiovascular and renal actions of a novel and newly synthesized 27-amino acid peptide termed vasonatrin peptide (VNP). VNP is a chimera of atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP). This synthetic peptide possesses the 22-amino acid structure of CNP, which is a cardiovascular selective peptide of endothelial origin and is structurally related...

Previous studies have demonstrated that the ventral aorta of the dogfish shark, Squalus acanthias, responds to a variety of cell-signaling agents. To investigate the generality of vasoactive receptors in the shark vasculature, in particular a conductance artery (anterior mesenteric) and vein (posterior intestinal), I measured the effect of acetylcholine, endothelin, nitric oxide, natriuretic pe...

the aim of the study was to evaluate the clinical usefulness of n-terminal pro-brain natriuretic peptide (nt-pro bnp) and nitric oxide (no) with echocardiography (gold standard test) in diagnosis of canine cardiomyopathy. out of 374 cases, 82 cases showing cardiovascular abnormalities including 16 cases of cardiomyopathy were further selected for standardization of biomarkers. significant (p

background: serum n-terminal pro-brain natriuretic peptide (nt-probnp), a polypeptide secreted by ventricular myocytes in response to stretch, was suggested as a predictor of adverse prognosis of the acute coronary syndrome (acs). we examined the association between nt-probnp level and angiographic findings in acs patients to determine whether it could be used as a predictor of the severity of ...

background: brain type natriuretic peptide (bnp) is a cardiac hormone that is secreted mainly by the ventricles in response to volume expansion and pressure load. it can predict post-operative complications after heart surgery in adults. we sought to investigate the prognostic value of bnp in children after heart surgery. methods: we measured the bnp serum levels in 96 children with congenital ...

background: n-terminal pro-brain natriuretic peptide (nt-probnp) is a sensitive biomarker for the detection of asymptomatic left ventricular (lv) dysfunction. since β-thalassemia major patients suffer from early diastolic dysfunction due to iron deposition of chronic blood transfusion, we tried to evaluate the correlation between the serum nt-probnp level and the severity of lv diastolic dysfun...