Abstract Ultracold neutrons (UCN), stored in a cell with hard walls that is attached to, and therefore rotating with, the Earth, will experience non-inertial frame effects, resulting in a broadening of the UCN spectrum. A heating or cooling of the spectrum is also possible. This is because the stored UCN are in a freely falling (inertial) frame between sudden wall collisions, and the accelerati...

6 We report experiments on the production of ultracold neutrons (UCN) in a converter of 7 superfluid helium coated with fluorinated grease. We employed our technique of window-free 8 extraction of accumulated UCN from the helium, in which they were produced by downscat9 tering neutrons of a cold beam from the Munich research reactor. The time constant for UCN 10 passage through the same extract...

7-Hydroxystaurosporine (UCN-01) infused for 72 hours by continuous i.v. infusion induced insulin resistance during phase I clinical trials. To understand the mechanism for this observation, we examined the effect of UCN-01 on insulinstimulated glucose transport activity with 3-O-methylglucose in isolated rat adipose cells. UCN-01 inhibits glucose transport activity in a dose-dependent manner at...

Skeletal muscle is the principal tissue responsible for insulin-stimulated glucose disposal and is a major site of peripheral insulin resistance. Urocortin 2 (Ucn 2), a member of the corticotropin-releasing factor (CRF) family, and its cognate type 2 CRF receptor (CRFR2) are highly expressed in skeletal muscle. To determine the physiological role of Ucn 2, we generated mice that are deficient i...

E2F-1 regulates the transcription of genes required for DNA synthesis. Previously, we have reported that UCN-01 suppresses E2F-1 protein expression without any noticeable effect on its mRNA level in gastric cancer cell line SK-GT5 (Clin. Cancer Res., 4: 2201-2206, 1998). In this study, we investigated the mechanism responsible for the suppression of E2F-1 expression by UCN-01 in SK-GT5 cells. A...

Urocortin is a neuropeptide belonging to the corticotrophin-releasing hormone family and is expressed by eutopic and ectopic human endometrium and the last years is investigated in the field of endometriosis. The objective of this systematic review is to accumulate current evidence related to the expression of urocortin in tissue and blood samples of patients suffering from endometriosis. Liter...

The vital role of the corticotropin-releasing factor (CRF) peptide family in the brain in coordinating response to stress has been extensively documented. The effects of CRF are mediated by two G-protein-coupled receptors, type 1 and type 2 CRF receptors (CRF(1) and CRF(2)). While the functional role of CRF(1) in hormonal and behavioral adaptation to stress is well-known, the physiological sign...

The spatial coordination of growth is of central importance for the regulation of plant tissue architecture. Individual layers, such as the epidermis, are clonally propagated and structurally maintained by symmetric cell divisions that are oriented along the plane of the layer. The developmental control of this process is poorly understood. The simple cellular basis and sheet-like structure of ...

Interactions between UCN-01 and HMG-CoA reductase inhibitors (ie, statins) have been examined in human leukemia and myeloma cells. Exposure of U937 and U266 cells to minimally toxic concentrations of UCN-01 and various statins (eg, lovastatin, simvastatin, or fluvastatin) dramatically increased mitochondrial dysfunction, caspase activation, and apoptosis. Comparable effects were observed in oth...

The reflectivity of ultracold neutron (UCN) guides produced with a dedicated technique called Replika has been studied. The guides are made of nickel, where the surface quality was copied from a glass layer. This results in a surface roughness smaller than 10 Å. The reflectivity was measured to be 99.9 % or higher. Those guides can be used at present or future UCN sources to transport UCN over ...