Human umbilical cord-derived mesenchymal stromal cells (hUCMSCs) are the most primitive of those isolated from other post-natal tissue source. The hUCMSCs possess the capability of differentiating along multi-lineage. This study aimed to investigate whether hUCMSCs can differentiate into urothelium-like cells. The hUCMSCs were isolated from fresh human umbilical cord postpartum and expanded at ...

conclusion our study revealed that the hypoplastic umbilical artery group’s non-dominant cia had higher ri values than the contralateral dominant cia. results eleven of the 165 patients (6.7%) demonstrated a hypoplastic umbilical artery. second-trimester us showed median dominant and non-dominant cia pi values of 1.43 and 1.60 (p = 0.062), respectively, and median dominant and non-dominant cia ...

Abstract Background Hepatic steatosis is a big hurdle to treat type 2 diabetes (T2D). Fasting-mimicking diet (FMD) has been shown be an effective intervention in dyslipidemia of T2D. However, fasting may impair the normal glucose metabolism. Human umbilical cord-derived mesenchymal stem cell (UC-MSC) transplantation discovered regulate immune reactions and reduce hyperglycemia diabetes. effect ...

Fibroblast-like cells with properties similar to mesenchymal stromal cells (MSCs) are present in human umbilical cord (hUC). In accordance with the international minimal criteria for defining multipotent mesenchymal stromal cells, hUC cells are designed MSCs being plastic adherent, positive to specific non hematopoietic lineage biomarkers, able to be both in vitro long term cultured and differe...

Abstract Background Mesenchymal stem cells (MSCs) have to be expanded in vitro reach a sufficient cell dose for the treatment of various diseases. During process expansion, some obstacles remain overcome. The purpose this study was investigate effects storage solutions and heterogeneity on behavior MSCs vivo. Methods Umbilical cord (UC-MSCs) similar sizes within normal ranges were suspended thr...

The human umbilical cord (UC) and placenta are non-invasive, primitive and abundant sources of mesenchymal stromal cells (MSCs) that have increasingly gained attention because they do not pose any ethical or moral concerns. Current methods to isolate MSCs from UC yield low amounts of cells with variable proliferation potentials. Since UC is an anatomically-complex organ, differences in MSC prop...

Intraventricular hemorrhage (IVH) is a frequent complication of preterm newborns, resulting in cerebral palsy and cognitive handicap as well as hypoxic ischemic encephalopathy and periventricular leukomalacia. In this study, we investigated the restorative effect on neonatal IVH by umbilical cord-derived mesenchymal stromal cells (UC-MSCs) cultured in serum-free medium (RM medium) for clinical ...

BACKGROUND Human umbilical cord mesenchymal stem cells (UC-MSCs) can regulate the function of immune cells. However, whether and how UC-MSCs can modulate the function of Vγ9Vδ2 T cells has not been fully understood. METHODS The PBMCs or Vγ9Vδ2 T cells were activated and expanded with pamidronate (PAM) and interleukin-2 (IL-2) with or without the presence UC-MSCs. The effects of UC-MSCs on the...

Nitric oxide (NO) bioavailability is fundamental in the regulation of redox balance and functionality endothelium, especially case umbilical cord (UC), which has no innervation. The analysis UC vessel-related complications could serve as a useful tool understanding pathophysiological mechanisms leading to neonatal cardiovascular disorders. Therefore, aim this study was characterize that rule se...