At concentrations of 5 «ig/mland greater the nonsteroidal antiinflammatory drug benoxaprofen caused dose-related activation of lucigeninenhanced chemiluminescence in human polymorphonuclear leukocytes (PMNL). Benoxaprofen-mediated activation of lucigenin-enhanced chemiluminescence by PMNL was increased by UV radiation and was particularly sensitive to inhibition by the selective protein kinase...

Forkhead box A1 (FOXA1) is an FKHD family pro-tein that plays pioneering roles in lineage-specificenhancer activation and gene transcription. Throughgenome-wide location analyses, here we show thatFOXA1 expression and occupancy are, in turn, re-quired for the maintenance of these epigeneticsignatures, namely DNA hypomethylation and his-tone 3 lysine 4 methylation. Me...

5-AminolevuHnate (ALA) photodynamic therapy (PDT) is being used clinically for the treatment of skin cancers. ALA is applied as a precursor of porphyrins serving as endogenous photosensitizers. Irradiation of HaCaT cells preincubated with 1 HIMALA for 24 h with red light of 570-750 nm at a dose of 4.5 .I/cm' leads to a 6-fold elevation of cellular c-Jun N-terminal kinase activity; phosphorylati...

Increased O(2) metabolism resulting in chronic hypoxia is common in models of endstage renal disease. Mitochondrial uncoupling increases O(2) consumption but the ensuing reduction in mitochondrial membrane potential may limit excessive oxidative stress. The present study addressed the hypothesis that mitochondrial uncoupling regulates mitochondria function and oxidative stress in the diabetic k...

The physiological function of human uncoupling protein-3 is still unknown. Uncoupling protein-3 is increased during fasting and high-fat feeding. In these situations the availability of fatty acids to the mitochondria exceeds the capacity to metabolize fatty acids, suggesting a role for uncoupling protein-3 in handling of non-metabolizable fatty acids. To test the hypothesis that uncoupling pro...

AIMS Both mitochondria and nitric oxide (NO*) contribute to cardioprotection by ischaemic preconditioning (IPC). IPC causes mild uncoupling of mitochondria via uncoupling proteins (UCPs) and the adenine nucleotide translocase (ANT), and mild uncoupling per se is cardioprotective. Although electrophilic lipids are known to activate mitochondrial uncoupling, the role of such species in IPC-induce...

Inappropriate nutrition and a sedentary lifestyle can lead to obesity, one of the most common risk factors for several chronic diseases. Although regular physical exercise is an efficient approach improve cardiometabolic health, exact cellular processes are still not fully understood. We aimed analyze morphological, gene expression, lipidomic patterns in liver adipose tissues response exercise....

abstract the feminist movement in the united states like other countries has tried to establish equality for women. from the first attempts to gain constitutional right for vote, up to the current radical demands, feminists have struggled to make changes in the u.s. party politics and obtain their rights within the parties. one of the important issues in which women played a key role in party p...

To determine if previously observed ef fects of dietary protein on hepatic cysteine metabolism were due specifically to increases in dietary protein or to the accompanying decreases in dietary carbohydrate, two experiments were conducted. In one experiment, rats were fed diets that contained different levels of protein vs. an isocaloric mixture of fat + cellulose and a constant amount of carboh...