background considering the significant geographical and ethnical differences in pattern of incidence, etiology and outcome of chronic kidney disease (ckd), the present study aimed to assess the etiology and outcome of ckd in iranian children. materials and methods in a cross-sectional study etiology and outcome of 372 children aged 3 months to 18 years with ckd was studied during the period 199...

background and objective: endocrine disorders are common in patients with chronic kidney disease (ckd). the aim of the present study is reviewing available literature to give a deep understanding of complexities of endocrine disorders in chronic kidney disease. methods: a narrative reviewing method based on the available literature was approached. findings: generally, when renal function decrea...

abstract objectives: interruption of rennin-angiotensin-aldosterone system has become a leading therapeutic strategy in the treatment of diabetic nephropathy however, aceis and arbs do not uniformly suppress the rennin-angiotensin-aldosterone system. plasma aldosterone levels are elevated in a group of patients despite therapy and this phenomenon known as aldosterone escape or aldosterone break...

the rise in the prevalence of chronic kidney disease (ckd) and an increase in the prevalence of obesity in parallel in the recent years is a great concern. ckd increases the rate of cardiovascular disease (cvd) and development of end-stage renal disease, and leads to premature death. although no direct causality link between obesity and ckd can yet be established, this appears highly probable. ...

• The diagnosis of kidney disease should be based on a glomerular filtration rate (GFR) < 60 mL/min/1.73 m 2 and/or the presence of kidney damage (manifested by persistent microalbuminuria, persistent proteinuria, persistent haematuria after exclusion of urological causes, or structural abnormalities on kidney imaging tests), irrespective of the underlying diagnosis. (Opinion) • A diagnosis of ...

chronic kidney disease (ckd) is a major public health problem that often goes unrecognized until late-stagedisease. patients with chronic kidney disease face with uremic toxins and hyperkalemia. also fluid overloadin ckd patients is associated with rapid decline in kidney function. lactulose is a hyper osmotic agent andas a prebiotic plays an important role in regulating serum urea and potassiu...

background: today, renal disease is one of the major worldwide health problems. it has a high prevalence, which increases 8% annually. incidence of renal disease and treatment techniques can affect the quality of life, health status and social roles of patients. the aim of the current study was to determine the quality of life of dialysis and kidney transplant patients and compare it to healthy...

Identifying genes underlying common forms of kidney disease in humans has proven difficult, expensive, and time consuming. Quantitative trait loci (QTL) for several complex traits are concordant among mice, rats, and humans, suggesting that genetic findings from these animal models are relevant to human disease. Therefore, we reviewed the literature on genetic studies of kidney disease in rat a...

BACKGROUND Mutation in several podocyte-specific genes have been noted to result in phenotypic heterogeneity. Herein, we report a novel, autosomal dominant TRPC6 mutation in a family with disease ranging from asymptomatic minimal change disease to end-stage kidney disease. CASE PRESENTATION A 35 year old woman developed asymptomatic, nephrotic range proteinuria during pregnancy that did not r...