Chitosan opens new perspectives in regenerative medicine as it enhances the properties of mesenchymal stem cells (MSCs) through formation of spheroids. Hypoxia has also been proposed to enhance stemness and survival of MSCs after in vivo implantation. These characteristics are relevant to the development of an off-the-shelf source of allogenic cells for regenerative therapy of tendinopathies. U...

Non-functional aspects including time constraints, distribution and fault tolerance are critical in the design and implementation of distributed realtime systems. As a result, it is well recognized that non-functional requirements should be considered at the earliest stages of system development life cycle. The ability to model non-functional properties (such as timing constraints, availability...

BACKGROUND Umbilical cord matrix mesenchymal stem cells (UCM-MSCs) present a wide range of potential therapeutical applications. The extracellular calcium-sensing receptor (CaSR) regulates physiological and pathological processes. We investigated, in a large animal model, the involvement of CaSR in triggering osteogenic and neurogenic differentiation of two size-sieved UCM-MSC lines, by using A...

Reported mechanical properties of orbital connective tissue and fat have been too sparse to model strain-stress relationships underlying biomechanical interactions in strabismus. We performed rheological tests to develop a multi-mode upper convected Maxwell (UCM) model of these tissues under shear loading. From 20 fresh bovine orbits, 30 samples of connective tissue were taken from rectus pulle...

The Use Case Maps (UCM) scenario notation is applicable to many requirements engineering activities. However, other scenario notations, such as Message Sequence Charts (MSC) and UML Sequence Diagrams (SD), have shown to be better suited for detailed design. In order to use the notation that is best appropriate for each phase in an efficient manner, a mechanism has to be devised to automatically...

Formal methods can be used at all stages of a software development project. In this paper we reflect on the roles of ITU-T standardized System Design Languages and their interplay in design processes of cooperative systems, highlighting the usability of User Requirements Notation (URN) standard to capture requirements with workflow-based re-engineering process of complex systems. In this paper ...

Scenario-driven requirement specifications are widely used to capture and represent functional requirements. Use Case Maps are being standardized as part of the User Requirements Notation (URN), the most recent addition to ITU-T’s family of languages. UCM models focus on the description of functional requirements and high-level designs at early stages of the development process. How a system is...